Negative Affectivity, Self-referential Processing and the Cortical Midline Structures

Overview

Journal Soc Cogn Affect Neurosci

Specialties Neurology
Social Sciences

Date 2010 Jun 4

PMID 20519253

Citations 39

Authors

Cedric Lemogne

Philip Gorwood

Loretxu Bergouignan

Antoine Pelissolo

Stephane Lehericy

Philippe Fossati

Affiliations

Soon will be listed here.

Abstract

The neural bases of the association between negative affectivity and self-focus remain unknown in healthy subjects. Building on the role of the cortical midline structures (CMS) in self-referential processing, we hypothesized that negative affectivity in healthy subjects would be associated with an increased activation of the CMS during self-referential processing. We presented positive and negative pictures to 45 healthy subjects during fMRI and asked them to judge whether the pictures were related to themselves or not (self condition), or whether the pictures were positive or negative (general condition). Negative affectivity was measured by the level of harm avoidance (HA) with the Temperament and Character Inventory. Self-referential processing activated the CMS, including the dorsal and ventral medial prefrontal cortex (MPFC) and the posterior cingulate cortex (PCC). A higher HA score was associated with a greater activation of the dorsal MPFC and PCC during self-referential processing, this greater activation being more pronounced for negative pictures in the dorsal MPFC. This increased activation of the CMS may embody the association between negative affectivity and self-focus in healthy subjects, as previously observed in major depression. Within the CMS, the dorsal MPFC may play a key role in negative affectivity, integrating an increased attention to negative stimuli with an increased attention to the self.

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References

Farmer R, Seeley J . Temperament and character predictors of depressed mood over a 4-year interval. Depress Anxiety. 2009; 26(4):371-81. DOI: 10.1002/da.20459. View

Grimm S, Ernst J, Boesiger P, Schuepbach D, Hell D, Boeker H . Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures. Hum Brain Mapp. 2009; 30(8):2617-27. PMC: 6870821. DOI: 10.1002/hbm.20693. View

Taylor S, Brown J . Illusion and well-being: a social psychological perspective on mental health. Psychol Bull. 1988; 103(2):193-210. View

Maldjian J, Laurienti P, Kraft R, Burdette J . An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003; 19(3):1233-9. DOI: 10.1016/s1053-8119(03)00169-1. View

Cloninger C, Svrakic D, Przybeck T . A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993; 50(12):975-90. DOI: 10.1001/archpsyc.1993.01820240059008. View

Sheline Y, Barch D, Price J, Rundle M, Vaishnavi S, Snyder A . The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A. 2009; 106(6):1942-7. PMC: 2631078. DOI: 10.1073/pnas.0812686106. View

Moran J, Macrae C, Heatherton T, Wyland C, Kelley W . Neuroanatomical evidence for distinct cognitive and affective components of self. J Cogn Neurosci. 2006; 18(9):1586-94. DOI: 10.1162/jocn.2006.18.9.1586. View

Lemogne C, Mayberg H, Bergouignan L, Volle E, Delaveau P, Lehericy S . Self-referential processing and the prefrontal cortex over the course of depression: a pilot study. J Affect Disord. 2009; 124(1-2):196-201. DOI: 10.1016/j.jad.2009.11.003. View

Grimm S, Boesiger P, Beck J, Schuepbach D, Bermpohl F, Walter M . Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology. 2008; 34(4):932-43. DOI: 10.1038/npp.2008.81. View

10.

Sheehan D, Lecrubier Y, Sheehan K, Amorim P, Janavs J, Weiller E . The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1999; 59 Suppl 20:22-33;quiz 34-57. View

11.

Yoshimura S, Okamoto Y, Onoda K, Matsunaga M, Ueda K, Suzuki S . Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. J Affect Disord. 2009; 122(1-2):76-85. DOI: 10.1016/j.jad.2009.06.017. View

12.

Lemogne C, le Bastard G, Mayberg H, Volle E, Bergouignan L, Lehericy S . In search of the depressive self: extended medial prefrontal network during self-referential processing in major depression. Soc Cogn Affect Neurosci. 2009; 4(3):305-12. PMC: 2728628. DOI: 10.1093/scan/nsp008. View

13.

Naghavi H, Lind J, Nilsson L, Adolfsson R, Nyberg L . Personality traits predict response to novel and familiar stimuli in the hippocampal region. Psychiatry Res. 2009; 173(2):94-9. DOI: 10.1016/j.pscychresns.2008.09.011. View

14.

Ono Y, Ando J, Onoda N, Yoshimura K, Momose T, Hirano M . Dimensions of temperament as vulnerability factors in depression. Mol Psychiatry. 2002; 7(9):948-53. DOI: 10.1038/sj.mp.4001122. View

15.

Lancaster J, Woldorff M, Parsons L, Liotti M, Freitas C, Rainey L . Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp. 2000; 10(3):120-31. PMC: 6871915. DOI: 10.1002/1097-0193(200007)10:3<120::aid-hbm30>3.0.co;2-8. View

16.

Johnson M, Raye C, Mitchell K, Touryan S, Greene E, Nolen-Hoeksema S . Dissociating medial frontal and posterior cingulate activity during self-reflection. Soc Cogn Affect Neurosci. 2008; 1(1):56-64. PMC: 2435374. DOI: 10.1093/scan/nsl004. View

17.

Cremers H, Demenescu L, Aleman A, Renken R, van Tol M, Van der Wee N . Neuroticism modulates amygdala-prefrontal connectivity in response to negative emotional facial expressions. Neuroimage. 2009; 49(1):963-70. DOI: 10.1016/j.neuroimage.2009.08.023. View

18.

Phan K, Taylor S, Welsh R, Ho S, Britton J, Liberzon I . Neural correlates of individual ratings of emotional salience: a trial-related fMRI study. Neuroimage. 2004; 21(2):768-80. DOI: 10.1016/j.neuroimage.2003.09.072. View

19.

Eisenberger N, Lieberman M, Satpute A . Personality from a controlled processing perspective: an fMRI study of neuroticism, extraversion, and self-consciousness. Cogn Affect Behav Neurosci. 2005; 5(2):169-81. DOI: 10.3758/cabn.5.2.169. View

20.

Cavanna A, Trimble M . The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 2006; 129(Pt 3):564-83. DOI: 10.1093/brain/awl004. View