MDRD or CKD-EPI Study Equations for Estimating Prevalence of Stage 3 CKD in Epidemiological Studies: Which Difference? Is This Difference Relevant?

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2010 Jun 3

PMID 20515483

Citations 17

Authors

Pierre Delanaye

Etienne Cavalier

Christophe Mariat

Nicolas Maillard

Jean-Marie Krzesinski

Affiliations

Soon will be listed here.

Abstract

Background: Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Recently, a new estimator based on creatinine, the CKD-EPI equation, has been proposed which is presumed to better perform in normal GFR ranges. The aim of the study was to measure the difference in prevalence of stage 3 CKD in a population using either the MDRD or the CKD-EPI study equations.

Methods: CKD screening is organized in the Province of Liège, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited to be screened. GFR is estimated by the MDRD study equation and by the "new" CKD-EPI equations.

Results: The population screened consisted in 1992 people (47% of men). Mean serum creatinine was 0.86 +/- 0.20 mg/dL. The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 11.04 and 7.98%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p < 0,0012).

Conclusions: Prevalence of stage 3 CKD varies strongly following the method used for estimating GFR, MDRD or CKD-EPI study equations. Such discrepancies are of importance and must be confirmed and explained by additional studies using GFR measured with a reference method.

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