Frequency of Endometriotic Lesions in Peritoneum Samples from Asymptomatic Fertile Women and Correlation with CA125 Values

Overview

Journal Sao Paulo Med J

Specialty General Medicine

Date 2010 Jun 1

PMID 20512287

Citations 15

Authors

Caio Parente Barbosa

Angela Mara Bentes de Souza

Bianca Bianco

Denise Christofolini

Fernanda Abani Mafra Bach

Geraldo Rodrigues de Lima

Affiliations

Soon will be listed here.

Abstract

Context And Objective: Serological testing for CA125 has been widely used to detect endometriosis and to monitor its progression. However, controversy still exists regarding the usefulness of the plasma CA125 assay for diagnosing endometriosis. Furthermore, some authors have described superficial endometriosis as a cyclical and normal phenomenon in women's lives, and have indicated that development and progression of this disease would only occur in some women as a result of immunological changes. This study aimed to determine the frequency of endometriosis and the correlation between serum CA125 levels and the presence of endometriotic lesions in the peritoneum of asymptomatic fertile patients.

Design And Setting: Cross-sectional study at the Family Planning outpatient clinic of Faculdade de Medicina do ABC.

Methods: Eighty asymptomatic fertile patients who underwent tubal sterilization surgery were studied. Blood and peritoneum samples were collected. CA125 levels were measured from blood samples, and peritoneum biopsies were studied using histopathological tests.

Results: Histopathological evaluation of the peritoneum revealed that 16.25% of the patients had minimal or mild endometriosis. There was no statistically significant difference in CA125 levels between patients with and without endometriosis.

Conclusion: The presence of endometriotic lesions in the peritoneum of fertile patients supports the hypothesis that incidental findings of minimal or mild endometriosis may not be of clinical significance, and that the progression of the disease probably occurs as a result of immunological and genetic abnormalities. Serum CA125 levels did not show any diagnostic significance with regard to detecting the disease.

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References

Koninckx P, Martin D . Deep endometriosis: a consequence of infiltration or retraction or possibly adenomyosis externa?. Fertil Steril. 1992; 58(5):924-8. DOI: 10.1016/s0015-0282(16)55436-3. View

Pittaway D, Rondinone D, Miller K, Barnes K . Clinical evaluation of CA-125 concentrations as a prognostic factor for pregnancy in infertile women with surgically treated endometriosis. Fertil Steril. 1995; 64(2):321-4. View

Amaral V, Ferriani R, Sa M, Nogueira A, Silva J, Japur de Sa Rosa E Silva A . Positive correlation between serum and peritoneal fluid CA-125 levels in women with pelvic endometriosis. Sao Paulo Med J. 2006; 124(4):223-7. PMC: 11065374. DOI: 10.1590/s1516-31802006000400010. View

Giudice L, Kao L . Endometriosis. Lancet. 2004; 364(9447):1789-99. DOI: 10.1016/S0140-6736(04)17403-5. View

Abrao M, Podgaec S, Filho B, Ramos L, PINOTTI J, de Oliveira R . The use of biochemical markers in the diagnosis of pelvic endometriosis. Hum Reprod. 1998; 12(11):2523-7. DOI: 10.1093/humrep/12.11.2523. View

Renner S, Strick R, Oppelt P, Fasching P, Engel S, Baumann R . Evaluation of clinical parameters and estrogen receptor alpha gene polymorphisms for patients with endometriosis. Reproduction. 2006; 131(1):153-61. DOI: 10.1530/rep.1.00787. View

Somigliana E, Vigano P, Tirelli A, Felicetta I, Torresani E, Vignali M . Use of the concomitant serum dosage of CA 125, CA 19-9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions. Hum Reprod. 2004; 19(8):1871-6. DOI: 10.1093/humrep/deh312. View

Niloff J, Knapp R, Jones G, Schaetzl E, Bast Jr R . Recombinant leukocyte alpha interferon in advanced ovarian carcinoma. Cancer Treat Rep. 1985; 69(7-8):895-6. View

Mahmood T, Templeton A . Prevalence and genesis of endometriosis. Hum Reprod. 1991; 6(4):544-9. DOI: 10.1093/oxfordjournals.humrep.a137377. View

10.

Dessole S, Farina M, Rubattu G, Cosmi E, Ambrosini G, Nardelli G . Sonovaginography is a new technique for assessing rectovaginal endometriosis. Fertil Steril. 2003; 79(4):1023-7. DOI: 10.1016/s0015-0282(02)04952-x. View

11.

. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997; 67(5):817-21. DOI: 10.1016/s0015-0282(97)81391-x. View

12.

Nisolle M, Anaf V, Mine J, Donnez J . Morphometric study of the stromal vascularization in peritoneal endometriosis. Fertil Steril. 1993; 59(3):681-4. View

13.

Kitawaki J, Ishihara H, Koshiba H, Kiyomizu M, Teramoto M, Kitaoka Y . Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas. Hum Reprod. 2005; 20(7):1999-2003. DOI: 10.1093/humrep/deh890. View

14.

Hoeger K, Guzick D . An update on the classification of endometriosis. Clin Obstet Gynecol. 1999; 42(3):611-9. DOI: 10.1097/00003081-199909000-00015. View

15.

Stratton P, Winkel C, Premkumar A, Chow C, Wilson J, Hearns-Stokes R . Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis. Fertil Steril. 2003; 79(5):1078-85. DOI: 10.1016/s0015-0282(03)00155-9. View

16.

Koninckx P, Meuleman C, Oosterlynck D, Cornillie F . Diagnosis of deep endometriosis by clinical examination during menstruation and plasma CA-125 concentration. Fertil Steril. 1996; 65(2):280-7. View

17.

Falconer H, Bambra C, Chai D, Cornillie F, Hill J, DHooghe T . The effect of endometriosis, cycle stage, lymphocyte suppression and pregnancy on CA-125 levels in peritoneal fluid and serum in baboons. Hum Reprod. 2005; 20(11):3033-8. DOI: 10.1093/humrep/dei181. View

18.

Missmer S, Cramer D . The epidemiology of endometriosis. Obstet Gynecol Clin North Am. 2003; 30(1):1-19, vii. DOI: 10.1016/s0889-8545(02)00050-5. View

19.

Vercellini P, Trespidi L, Panazza S, Bramante T, Mauro F, Crosignani P . Laparoscopic uterine biopsy for diagnosing diffuse adenomyosis. J Reprod Med. 1996; 41(4):220-4. View

20.

Cheng Y, Wang S, Chou C . Serum CA-125 in preoperative patients at high risk for endometriosis. Obstet Gynecol. 2002; 99(3):375-80. DOI: 10.1016/s0029-7844(01)01731-8. View