Frequency of Subclinical Thyroid Dysfunction and Risk Factors for Cardiovascular Disease Among Women at a Workplace

Overview

Journal Sao Paulo Med J

Specialty General Medicine

Date 2010 Jun 1

PMID 20512276

Citations 6

Authors

Rodrigo Diaz-Olmos

Antonio-Carlos Nogueira

Daniele Queiros Fucciolo Penalva

Paulo Andrade Lotufo

Isabela Martins Bensenor

Affiliations

Soon will be listed here.

Abstract

Context And Objective: Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them.

Design And Setting: Cross-sectional study on 314 women aged 40 years or over who were working at Universidade de São Paulo (USP).

Methods: All the women answered a questionnaire on sociodemographic characteristics and risk factors for cardiovascular disease and the Rose angina questionnaire. Anthropometric variables were measured and blood samples were analyzed for blood glucose, total cholesterol and fractions, high-sensitivity C-reactive protein, thyroid-stimulating hormone (TSH), free thyroxine (free-T4) and anti-thyroperoxidase antibodies (anti-TPO).

Results: The frequencies of subclinical hypothyroidism and hyperthyroidism were, respectively, 7.3% and 5.1%. Women with subclinical thyroid disease presented higher levels of anti-TPO than did women with normal thyroid function (P = 0.01). There were no differences in sociodemographic factors and cardiovascular risk factors according to thyroid function status, except for greater sedentarism among the women with subclinical hypothyroidism. Restricting the comparison to women with subclinical hypothyroidism (TSH > 10 mIU/l) did not change the results.

Conclusion: In this sample of women, there was no association between poor profile of cardiovascular risk factors and presence of subclinical thyroid disease that would justify screening at the workplace.

Citing Articles

A study of the cardiac risk factors emerging out of subclinical hypothyroidism.

Dey A, Kanneganti V, Das D J Family Med Prim Care. 2019; 8(7):2439-2444.

PMID: 31463273 PMC: 6691448. DOI: 10.4103/jfmpc.jfmpc_348_19.

Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Bensenor I Braz J Med Biol Res. 2019; 52(2):e8417.

PMID: 30785482 PMC: 6376318. DOI: 10.1590/1414-431X20198417.

Pattern of thyroid dysfunction in patients with metabolic syndrome and its relationship with components of metabolic syndrome.

Gyawali P, Takanche J, Shrestha R, Bhattarai P, Khanal K, Risal P Diabetes Metab J. 2015; 39(1):66-73.

PMID: 25729715 PMC: 4342539. DOI: 10.4093/dmj.2015.39.1.66.

Endobiogeny: a global approach to systems biology (part 2 of 2).

Lapraz J, Hedayat K, Pauly P Glob Adv Health Med. 2014; 2(2):32-44.

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Evolution of subclinical hypothyroidism and its relation with glucose and triglycerides levels in morbidly obese patients after undergoing sleeve gastrectomy as bariatric procedure.

Ruiz-Tovar J, Boix E, Galindo I, Zubiaga L, Diez M, Arroyo A Obes Surg. 2013; 24(5):791-5.

PMID: 24347349 DOI: 10.1007/s11695-013-1150-5.

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