Seasonal Variation in the Effect of Constant Ambient Temperature of 24 Degrees C in Reducing FDG Uptake by Brown Adipose Tissue in Children

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2010 May 28

PMID 20505932

Citations 18

Authors

Katherine A Zukotynski

Frederic H Fahey

Stephen Laffin

Royal Davis

S Ted Treves

Frederick D Grant

Laura A Drubach

Affiliations

Soon will be listed here.

Abstract

Purpose: It has been shown that warming patients prior to and during (18)F-FDG uptake by controlling the room temperature can decrease uptake by brown adipose tissue (BAT). The aim of this study is to determine if this effect is subject to seasonal variation.

Methods: A retrospective review was conducted of all patients referred for whole-body (18)F-FDG PET between December 2006 and December 2008. After December 2007, all patients were kept in the PET injection room at a constant 24 degrees C for 30 min before and until 1 h following FDG administration. Patients over 22 years of age and those who received pre-medication known to reduce FDG uptake by BAT were excluded. One hundred and three patients were warmed to 24 degrees C prior to scanning. The number of patients showing uptake by BAT in this group was compared to a control group of 99 patients who underwent PET prior to December 2007 when the injection room temperature was 21 degrees C.

Results: Uptake by BAT occurred in 9% of studies performed after patient warming (24 degrees C), compared to 27% of studies performed on the control group (21 degrees C) (p < 0.00001). The effect of warming on decreasing FDG accumulation in BAT was statistically significant in the winter (p < 0.005) and summer (p < 0.001). However, in the spring and autumn, though the effect of warming on decreasing FDG accumulation in BAT was evident, it was not statistically significant (p > 0.05).

Conclusion: Maintaining room temperature at a constant 24 degrees C for 30 min prior to and 1 h after IV tracer administration significantly decreases FDG uptake by BAT in children. This effect is greatest in the summer and winter.

Citing Articles

Seasonal changes and decrease of suicides and suicide attempts in France over the last 10 years.

Akkaoui M, Chan-Chee C, Laaidi K, Fifre G, Lejoyeux M, Vaiva G Sci Rep. 2022; 12(1):8231.

PMID: 35581322 PMC: 9114420. DOI: 10.1038/s41598-022-12215-3.

The effect of seasonal changes and climatic factors on suicide attempts of young people.

Akkaya-Kalayci T, Vyssoki B, Winkler D, Willeit M, Kapusta N, Dorffner G BMC Psychiatry. 2017; 17(1):365.

PMID: 29141599 PMC: 5688742. DOI: 10.1186/s12888-017-1532-7.

Long-term exposure to space's microgravity alters the time structure of heart rate variability of astronauts.

Otsuka K, Cornelissen G, Furukawa S, Kubo Y, Hayashi M, Shibata K Heliyon. 2017; 2(12):e00211.

PMID: 28050606 PMC: 5192238. DOI: 10.1016/j.heliyon.2016.e00211.

Imaging of Brown Adipose Tissue: State of the Art.

Sampath S, Sampath S, Bredella M, Cypess A, Torriani M Radiology. 2016; 280(1):4-19.

PMID: 27322970 PMC: 4942993. DOI: 10.1148/radiol.2016150390.

Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.

Wang Q, Zhang M, Xu M, Gu W, Xi Y, Qi L PLoS One. 2015; 10(4):e0123795.

PMID: 25894250 PMC: 4403996. DOI: 10.1371/journal.pone.0123795.

References

Ronti T, Lupattelli G, Mannarino E . The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf). 2006; 64(4):355-65. DOI: 10.1111/j.1365-2265.2006.02474.x. View

Yang X, Enerback S, Smith U . Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes Res. 2003; 11(10):1182-91. DOI: 10.1038/oby.2003.163. View

Cohade C, Osman M, Pannu H, Wahl R . Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT. J Nucl Med. 2003; 44(2):170-6. View

Wehrli N, Bural G, Houseni M, Alkhawaldeh K, Alavi A, Torigian D . Determination of age-related changes in structure and function of skin, adipose tissue, and skeletal muscle with computed tomography, magnetic resonance imaging, and positron emission tomography. Semin Nucl Med. 2007; 37(3):195-205. DOI: 10.1053/j.semnuclmed.2007.02.002. View

Cannon B, Nedergaard J . Developmental biology: Neither fat nor flesh. Nature. 2008; 454(7207):947-8. DOI: 10.1038/454947a. View

Tatsumi M, Engles J, Ishimori T, Nicely O, Cohade C, Wahl R . Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med. 2004; 45(7):1189-93. View

Garcia C, Van Nostrand D, Majd M, Atkins F, Acio E, Sheikh A . Benzodiazepine-resistant "brown fat" pattern in positron emission tomography: two case reports of resolution with temperature control. Mol Imaging Biol. 2004; 6(6):368-72. DOI: 10.1016/j.mibio.2004.08.003. View

Heaton J . The distribution of brown adipose tissue in the human. J Anat. 1972; 112(Pt 1):35-9. PMC: 1271341. View

Himms-Hagen J . Thermogenesis in brown adipose tissue as an energy buffer. Implications for obesity. N Engl J Med. 1984; 311(24):1549-58. DOI: 10.1056/NEJM198412133112407. View

10.

Sturkenboom M, Hoekstra O, Postema E, Zijlstra J, Berkhof J, Franssen E . A randomised controlled trial assessing the effect of oral diazepam on 18F-FDG uptake in the neck and upper chest region. Mol Imaging Biol. 2009; 11(5):364-8. PMC: 2719725. DOI: 10.1007/s11307-009-0207-2. View

11.

Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J . High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009; 58(7):1526-31. PMC: 2699872. DOI: 10.2337/db09-0530. View

12.

Lazar M . How obesity causes diabetes: not a tall tale. Science. 2005; 307(5708):373-5. DOI: 10.1126/science.1104342. View

13.

Lowell B, Hamann A, Lawitts J, Himms-Hagen J, Boyer B, Kozak L . Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993; 366(6457):740-2. DOI: 10.1038/366740a0. View

14.

Kushi L, Byers T, Doyle C, Bandera E, McCullough M, McTiernan A . American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2006; 56(5):254-81. DOI: 10.3322/canjclin.56.5.254. View

15.

Paidisetty S, Blodgett T . Brown fat: atypical locations and appearances encountered in PET/CT. AJR Am J Roentgenol. 2009; 193(2):359-66. DOI: 10.2214/ajr.08.2081. View

16.

Soderlund V, Larsson S, Jacobsson H . Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging. 2007; 34(7):1018-22. DOI: 10.1007/s00259-006-0318-9. View

17.

Kim S, Krynyckyi B, Machac J, Kim C . Temporal relation between temperature change and FDG uptake in brown adipose tissue. Eur J Nucl Med Mol Imaging. 2007; 35(5):984-9. DOI: 10.1007/s00259-007-0670-4. View

18.

Garcia C, Van Nostrand D, ATKINS F, Acio E, Butler C, Esposito G . Reduction of brown fat 2-deoxy-2-[F-18]fluoro-D-glucose uptake by controlling environmental temperature prior to positron emission tomography scan. Mol Imaging Biol. 2005; 8(1):24-9. DOI: 10.1007/s11307-005-0030-3. View

19.

Hany T, Gharehpapagh E, Kamel E, Buck A, Himms-Hagen J, von Schulthess G . Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging. 2002; 29(10):1393-8. DOI: 10.1007/s00259-002-0902-6. View

20.

Truong M, Erasmus J, Munden R, Marom E, Sabloff B, Gladish G . Focal FDG uptake in mediastinal brown fat mimicking malignancy: a potential pitfall resolved on PET/CT. AJR Am J Roentgenol. 2004; 183(4):1127-32. DOI: 10.2214/ajr.183.4.1831127. View