Erythema Multiforme Caused by Treponema Pallidum in a Young Patient with Human Immunodeficiency Virus Infection

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2010 May 28

PMID 20504989

Citations 3

Authors

Mei-Chun Chiang

Fu-Chiang Chiang

Yun-Ting Chang

Te-Li Chen

Chang-Phone Fung

Affiliations

Soon will be listed here.

Abstract

Erythema multiforme (EM) is usually caused by drug reactions or virus infection. We report a case of secondary syphilis presenting as EM in an HIV-infected patient, proved by immunohistochemical staining, which is rare in the literature. It is valuable to determine the etiology of EM to optimize treatment.

Citing Articles

Secondary Syphilis Presenting as Erythema Multiforme in the Setting of AIDS and Psoriasis.

Cook O, Knafo J, Bhaskar R, Salhab M, Nguyen H Cureus. 2022; 14(9):e29110.

PMID: 36259021 PMC: 9559528. DOI: 10.7759/cureus.29110.

Immunohistochemical diagnosis of human infectious diseases: a review.

Oumarou Hama H, Aboudharam G, Barbieri R, Lepidi H, Drancourt M Diagn Pathol. 2022; 17(1):17.

PMID: 35094696 PMC: 8801197. DOI: 10.1186/s13000-022-01197-5.

Secondary Syphilis Presenting As Palmoplantar Psoriasis.

Gianfaldoni S, Tchernev G, Wollina U, Gianfaldoni R, Lotti T Open Access Maced J Med Sci. 2017; 5(4):445-447.

PMID: 28785328 PMC: 5535653. DOI: 10.3889/oamjms.2017.087.

References

LESINSKI J, KRACH J, Kadziewicz E . Specificity, sensitivity, and diagnostic value of the TPHA test. Br J Vener Dis. 1974; 50(5):334-40. PMC: 1045058. DOI: 10.1136/sti.50.5.334. View

Huff J, Weston W, Tonnesen M . Erythema multiforme: a critical review of characteristics, diagnostic criteria, and causes. J Am Acad Dermatol. 1983; 8(6):763-75. DOI: 10.1016/s0190-9622(83)80003-6. View

Lee J, Lee E . Erythema multiforme-like lesions in syphilis. Br J Dermatol. 2003; 149(3):658-60. DOI: 10.1046/j.1365-2133.2003.05512.x. View

Al-Johani K, Fedele S, Porter S . Erythema multiforme and related disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103(5):642-54. DOI: 10.1016/j.tripleo.2006.12.008. View

Farthing P, Bagan J, Scully C . Mucosal disease series. Number IV. Erythema multiforme. Oral Dis. 2005; 11(5):261-7. DOI: 10.1111/j.1601-0825.2005.01141.x. View

Tonnesen M, Soter N . Erythema multiforme. J Am Acad Dermatol. 1979; 1(4):357-64. DOI: 10.1016/s0190-9622(79)70030-2. View

Mockenhaupt M, Naldi L, Correia O, Schroder W, Roujeau J . Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol. 2002; 138(8):1019-24. DOI: 10.1001/archderm.138.8.1019. View

ONeill P . A new look at the serology of treponemal disease. Br J Vener Dis. 1976; 52(5):296-9. PMC: 1045288. DOI: 10.1136/sti.52.5.296. View

Behrhof W, Springer E, Brauninger W, Kirkpatrick C, Weber A . PCR testing for Treponema pallidum in paraffin-embedded skin biopsy specimens: test design and impact on the diagnosis of syphilis. J Clin Pathol. 2007; 61(3):390-5. DOI: 10.1136/jcp.2007.046714. View

10.

Hoang M, High W, Molberg K . Secondary syphilis: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2004; 31(9):595-9. DOI: 10.1111/j.0303-6987.2004.00236.x. View

11.

Coopman S, Johnson R, Platt R, Stern R . Cutaneous disease and drug reactions in HIV infection. N Engl J Med. 1993; 328(23):1670-4. DOI: 10.1056/NEJM199306103282304. View

12.

Kim Y, Lee J, Yoon S, Lee J, Cho S . Erythema multiforme-like targetoid lesions in secondary syphilis. Acta Derm Venereol. 2007; 87(4):381-2. DOI: 10.2340/00015555-0252. View

13.

Dylewski J, Duong M . The rash of secondary syphilis. CMAJ. 2007; 176(1):33-5. PMC: 1764588. DOI: 10.1503/cmaj.060665. View