Determinants of IGF1 and GH Across the Weight Spectrum: from Anorexia Nervosa to Obesity

Overview

Journal Eur J Endocrinol

Publisher Oxford University Press

Specialty Endocrinology

Date 2010 May 27

PMID 20501597

Citations 22

Authors

D J Brick

A V Gerweck

E Meenaghan

E A Lawson

M Misra

P Fazeli

W Johnson

A Klibanski

K K Miller

Affiliations

Soon will be listed here.

Abstract

Context: Chronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal.

Objective: To investigate the determinants of IGF1 and GH across the weight spectrum in women.

Design: Cross-sectional study.

Setting: Clinical research center.

Study Participants: In total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age.

Intervention: None.

Main Outcome Measures: Pooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E(2)), testosterone, SHBG, insulin, free fatty acids, and trunk fat.

Results: Free testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E(2) (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded.

Conclusions: Free testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.

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