Biologic Markers in Risk Assessment for Environmental Carcinogens

Overview

Journal Environ Health Perspect

Date 1991 Jan 1

PMID 2050068

Citations 8

Authors

F Perera

J Mayer

R M Santella

D Brenner

A Jeffrey

L Latriano

S Smith

D Warburton

T L Young

W Y Tsai

Affiliations

Soon will be listed here.

Abstract

The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular epidemiology. Biologic markers such as carcinogen-DNA adducts and oncogene activation are currently considered valid qualitative indicators of potential risk, but for most chemical exposures research is needed to establish their validity as quantitative predictors of cancer risk. Biologic markers have, however, already provided valuable insights into the magnitude of interindividual variation in response to carcinogenic exposures, with major implications for risk assessment.

Citing Articles

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Evaluation of health risks for contaminated aquifers.

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Use of biologic markers for toxic end-points in assessment of risks from exposure to chemicals.

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Monitoring human exposure to urban air pollutants.

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Analysis of cigarette-smoke-induced DNA adducts by butanol extraction and nuclease P1-enhanced 32P-postlabeling in human lymphocytes and granulocytes.

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