The Expressions of Inflammatory Factors and Tissue Inhibitor of Matrix Metalloproteinase-2 in Human Chronic Periodontitis with Type 2 Diabetes Mellitus

Overview

Journal J Periodontal Implant Sci

Specialty Dentistry

Date 2010 May 26

PMID 20498757

Citations 4

Authors

Dong-Seok Shin

Jin-Woo Park

Jo-Young Suh

Jae-Mok Lee

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.

Methods: Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey's test.

Results: The expression levels of IFN-gamma and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.

Conclusions: The findings suggest that IFN-gamma and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.

Citing Articles

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Expression of Inflammatory Mediators in Periodontitis Over Established Diabetes: an Experimental Study in Rats.

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Levels of Myeloperoxidase and Metalloproteinase-9 in Gingival Crevicular Fluid from Diabetic Subjects with and without Stage 2, Grade B Periodontitis.

Peniche-Palma D, Carrillo-Avila B, Sauri-Esquivel E, Acosta-Viana K, Esparza-Villalpando V, Pozos-Guillen A Biomed Res Int. 2019; 2019:5613514.

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Crestal Bone Loss Around Submerged and Non-Submerged Dental Implants in Individuals with Type-2 Diabetes Mellitus: A 7-Year Prospective Clinical Study.

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