Manserin, a Secretogranin II-derived Peptide, Distributes in the Rat Endocrine Pancreas Colocalized with Islet-cell Specific Manner

Overview

Journal Histochem Cell Biol

Publisher Springer

Specialties Biochemistry
Cell Biology

Date 2010 May 25

PMID 20495819

Citations 3

Authors

Kaori Tano

Akiko Oyabu

Yasura Tashiro

Naoki Kamada

Naoko Narita

Fumio Nasu

Masaaki Narita

Affiliations

Soon will be listed here.

Abstract

Manserin is a recently characterized 40-amino acid neuropeptide derived from secretogranin II, a protein belonging to the chromogranin family. Although the physiological roles of manserin have not been elucidated to date, manserin has been shown to distribute in not only the brain but also the endocrine system such as the pituitary and adrenal glands, suggesting its role in the endocrine system. The present study aimed to explore the occurrence and distribution of manserin in the rat pancreas using an immunohistochemical technique with a polyclonal antibody against rat manserin. Immunoreactivity for manserin was readily detected in almost whole islets of Langerhans whereas not at all in the exocrine pancreas. Manserin-expressing cells were not colocalized with the glucagon-secreting cells (alpha cells), whereas they colocalized with insulin-secreting cells (beta cells) and somatostatin-secreting cells (delta cells), although their intracellular distribution was different. These results indicate that manserin, occurring in the endocrine pancreas, may have a potential role in the endocrine system.

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References

Zhao E, Basak A, Wong A, Ko W, Chen A, Lopez G . The secretogranin II-derived peptide secretoneurin stimulates luteinizing hormone secretion from gonadotrophs. Endocrinology. 2008; 150(5):2273-82. DOI: 10.1210/en.2008-1060. View

Zhao E, Zhang D, Basak A, Trudeau V . New insights into granin-derived peptides: evolution and endocrine roles. Gen Comp Endocrinol. 2009; 164(2-3):161-74. DOI: 10.1016/j.ygcen.2009.01.011. View

Marchese A, George S, Kolakowski Jr L, Lynch K, ODowd B . Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol Sci. 1999; 20(9):370-5. DOI: 10.1016/s0165-6147(99)01366-8. View

Conlon J . Granin-derived peptides as diagnostic and prognostic markers for endocrine tumors. Regul Pept. 2009; 165(1):5-11. DOI: 10.1016/j.regpep.2009.11.013. View

Schally A, Arimura A, Baba Y, Nair R, Matsuo H, Redding T . Isolation and properties of the FSH and LH-releasing hormone. Biochem Biophys Res Commun. 1971; 43(2):393-9. DOI: 10.1016/0006-291x(71)90766-2. View

Courel M, Vasquez M, Hook V, Mahata S, Taupenot L . Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains. J Biol Chem. 2008; 283(17):11807-22. PMC: 2431052. DOI: 10.1074/jbc.M709832200. View

Taupenot L, Harper K, OConnor D . The chromogranin-secretogranin family. N Engl J Med. 2003; 348(12):1134-49. DOI: 10.1056/NEJMra021405. View

Montero-Hadjadje M, Pelletier G, Yon L, Li S, Guillemot J, Magoul R . Biochemical characterization and immunocytochemical localization of EM66, a novel peptide derived from secretogranin II, in the rat pituitary and adrenal glands. J Histochem Cytochem. 2003; 51(8):1083-95. DOI: 10.1177/002215540305100812. View

Takahashi T, Muneoka Y, Lohmann J, Lopez de Haro M, Solleder G, Bosch T . Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families. Proc Natl Acad Sci U S A. 1997; 94(4):1241-6. PMC: 19775. DOI: 10.1073/pnas.94.4.1241. View

10.

Yajima A, Narita N, Narita M . Recently identified a novel neuropeptide manserin colocalize with the TUNEL-positive cells in the top villi of the rat duodenum. J Pept Sci. 2008; 14(6):773-6. DOI: 10.1002/psc.991. View

11.

Trandaburu T, Syed Ali S, Trandaburu I . Granin proteins (chromogranin A and secretogranin II C23-3 and C26-3) in the endocrine pancreas of reptiles. Ann Anat. 1999; 181(5):489-94. DOI: 10.1016/S0940-9602(99)80032-6. View

12.

Tatemoto K, Mutt V . Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature. 1980; 285(5764):417-8. DOI: 10.1038/285417a0. View

13.

Helle K . Regulatory peptides from chromogranin A and secretogranin II: putative modulators of cells and tissues involved in inflammatory conditions. Regul Pept. 2009; 165(1):45-51. DOI: 10.1016/j.regpep.2009.09.009. View

14.

Fischer-Colbrie R, Kirchmair R, Kahler C, Wiedermann C, Saria A . Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. Curr Protein Pept Sci. 2005; 6(4):373-85. DOI: 10.2174/1389203054546334. View

15.

LEITNER B, Fischer-Colbrie R, Scherzer G, Winkler H . Secretogranin II: relative amounts and processing to secretoneurin in various rat tissues. J Neurochem. 1996; 66(3):1312-7. DOI: 10.1046/j.1471-4159.1996.66031312.x. View

16.

Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T . Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats. Arch Histol Cytol. 2004; 67(1):57-64. DOI: 10.1679/aohc.67.57. View

17.

Yajima A, Ikeda M, Miyazaki K, Maeshima T, Narita N, Narita M . Manserin, a novel peptide from secretogranin II in the neuroendocrine system. Neuroreport. 2004; 15(11):1755-9. DOI: 10.1097/01.wnr.0000127634.38052.84. View

18.

Portela-Gomes G, Grimelius L, Stridsberg M . Prohormone convertases 1/3, 2, furin and protein 7B2 (Secretogranin V) in endocrine cells of the human pancreas. Regul Pept. 2007; 146(1-3):117-24. DOI: 10.1016/j.regpep.2007.09.019. View

19.

ERSPAMER V, MELCHIORRI P, Erspamer C, Negri L . Polypeptides of the amphibian skin active on the gut and their mammalian counterparts. Adv Exp Med Biol. 1978; 106:51-64. DOI: 10.1007/978-1-4684-7248-6_6. View

20.

Stridsberg M, Grimelius L, Portela-Gomes G . Immunohistochemical staining of human islet cells with region-specific antibodies against secretogranins II and III. J Anat. 2008; 212(3):229-34. PMC: 2408995. DOI: 10.1111/j.1469-7580.2008.00857.x. View