Parental Report of Behavioral and Cognitive Diagnoses in Childhood-onset Epilepsy: A Case-sibling-controlled Analysis

Overview

Journal Epilepsy Behav

Specialties Neurology
Psychology
Social Sciences

Date 2010 May 25

PMID 20494622

Citations 5

Authors

Emma K T Benn

Dale C Hesdorffer

Susan R Levy

Francine M Testa

Francis J DiMario

Anne T Berg

Affiliations

Soon will be listed here.

Abstract

Evidence from multiple sources has highlighted the increased burden of cognitive, behavioral, and psychiatric disorders in childhood-onset epilepsy. Some of this increased morbidity, however, is attributable to underlying structural and metabolic insults. We assessed whether cognitive/behavioral/psychiatric disorders are associated with epilepsy of unknown or presumed genetic cause in young people with epilepsy (cases) compared with sibling controls. Our analyses included 217 cases who were enrolled in the Connecticut Study of Epilepsy between 1993 and 1997 and 217 sibling controls. Information was collected from a parent interview conducted 8-9years after the case was diagnosed with epilepsy. Relative to controls, parents were more likely to report that their case children were slow learners (OR=4.6, P<0.001), had a language disorder (OR=5.8, P<0.001), and had engaged in self-injurious behaviors other than suicide attempts (OR=5.5, P=0.013). Future research should examine whether these conditions first present during childhood influence prognosis into adulthood.

Citing Articles

Control groups in paediatric epilepsy research: do first-degree cousins show familial effects?.

Hanson M, Morrison B, Jones J, Jackson D, Almane D, Seidenberg M Epileptic Disord. 2017; 19(1):49-58.

PMID: 28351825 PMC: 6415294. DOI: 10.1684/epd.2017.0898.

Psychiatric disorders and suicidal behavior in neurotypical young adults with childhood-onset epilepsy.

Baldin E, Hesdorffer D, Caplan R, Berg A Epilepsia. 2015; 56(10):1623-8.

PMID: 26387857 PMC: 4602170. DOI: 10.1111/epi.13123.

Cortical organization of language pathways in children with non-localized cryptogenic epilepsy.

Frye R, Liederman J Front Hum Neurosci. 2014; 8:808.

PMID: 25346681 PMC: 4191195. DOI: 10.3389/fnhum.2014.00808.

Fluency patterns in narratives from children with localization related epilepsy.

Steinberg M, Ratner N, Gaillard W, Berl M J Fluency Disord. 2013; 38(2):193-205.

PMID: 23773671 PMC: 3687359. DOI: 10.1016/j.jfludis.2013.01.003.

Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy.

Berg A, Caplan R, Hesdorffer D Epilepsy Behav. 2011; 20(3):550-5.

PMID: 21315660 PMC: 3062749. DOI: 10.1016/j.yebeh.2010.12.038.

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