Polarity and Endocytosis: Reciprocal Regulation

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2010 May 25

PMID 20493706

Citations 63

Authors

Jessica M Shivas

Holly A Morrison

David Bilder

Ahna R Skop

Affiliations

Soon will be listed here.

Abstract

The establishment and maintenance of polarized plasma membrane domains is essential for cellular function and proper development of organisms. The molecules and pathways involved in determining cell polarity are remarkably well conserved between animal species. Historically, exocytic mechanisms have received primary emphasis among trafficking routes responsible for cell polarization. Accumulating evidence now reveals that endocytosis plays an equally important role in the proper localization of key polarity proteins. Intriguingly, some polarity proteins can also regulate the endocytic machinery. Here, we review emerging evidence for the reciprocal regulation between polarity proteins and endocytic pathways, and discuss possible models for how these distinct processes could interact to create separate cellular domains.

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