The Pharmacokinetics of Postoperative Intravenous Ketorolac Tromethamine in Children

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1991 Feb 1

PMID 2049235

Citations 12

Authors

K T Olkkola

E L Maunuksela

Affiliations

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Abstract

Ketorolac tromethamine (0.5 mg kg-1) was given intravenously to 10 children (age 4-8 years) after minor surgery. Values of steady-state volume of distribution and plasma clearance were approximately two times higher than those in adults but values of elimination half-life were similar.

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References

Boxenbaum H, RIEGELMAN S, Elashoff R . Statistical estimations in pharmacokinetics. J Pharmacokinet Biopharm. 1974; 2(2):123-48. DOI: 10.1007/BF01061504. View

Gibaldi M, Koup J . Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance. Eur J Clin Pharmacol. 1981; 20(4):299-305. DOI: 10.1007/BF00618781. View

Bloomfield S, Mitchell J, Cissell G, BARDEN T, Yee J . Ketorolac versus aspirin for postpartum uterine pain. Pharmacotherapy. 1986; 6(5):247-52. DOI: 10.1002/j.1875-9114.1986.tb03484.x. View

Jung D, Mroszczak E, Bynum L . Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration. Eur J Clin Pharmacol. 1988; 35(4):423-5. DOI: 10.1007/BF00561376. View

Maunuksela E, Olkkola K, Korpela R . Measurement of pain in children with self-reporting and behavioral assessment. Clin Pharmacol Ther. 1987; 42(2):137-41. DOI: 10.1038/clpt.1987.123. View