Anthracenedione Derivatives As Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2010 May 19

PMID 20479985

Citations 39

Authors

Jian-Ye Zhang

Li-yang Tao

Yong-ju Liang

Li-Ming Chen

Yan-Jun Mi

Li-Sheng Zheng

Fang Wang

Zhi-Gang She

Yong-Cheng Lin

Kenneth Kin Wah To

Li-wu Fu

Affiliations

Soon will be listed here.

Abstract

In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC(50) values of 3.17 and 3.21 microM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.

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