Epidermal Lipids, Barrier Function, and Desquamation

Overview

Journal J Invest Dermatol

Publisher Elsevier

Specialty Dermatology

Date 2010 May 19

PMID 20479733

Citations 79

Authors

P M Elias

Affiliations

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Abstract

Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.

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