Cardiovascular Risk Factors and Noninvasive Assessment of Arterial Structure and Function in Obese Turkish Children

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2010 May 18

PMID 20473519

Citations 11

Authors

Murat Muhtar Yilmazer

Vedide Tavli

Ozgur Umac Carti

Timur Mese

Baris Guven

Banu Aydin

Ilker Devrim

Talat Tavli

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with a number of risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension, and early atherosclerosis. Evidence indicates that atherosclerosis begins in childhood and progresses over decades. In this work, we examined the relationship between cardiovascular risk factors and ultrasonographic signs of subclinical atherosclerosis in 77 obese children and adolescents compared to 40 non-obese healthy peers. Carotis intima media thickness (cIMT), carotid artery compliance (CAC), brachial artery flow-mediated dilatation (FMD), and established cardiovascular risk factors were studied. In the obese patients, cIMT was significantly increased (0.57 mm vs 0.45 mm, p < 0.001) whereas CAC (1.84% vs 3.29%, p < 0.001) and FMD (9.67 % vs 14.81%, p < 0.001) were significantly decreased. In multiple linear regression analysis, a relation was observed between cIMT, CAC, brachial FMD on one hand, and body mass index (BMI) on the other. Among the lipid anomalies, only hypertriglyceridemia was found to be positively correlated with cIMT. Additionally, we found a significant association between waist circumference (WC) and FMD. These findings indicate that obesity in children is associated with arterial wall alterations and endothelial dysfunction. In hyperlipidemic situations, only hypertriglyceridemia was found to be positively correlated with cIMT. This finding has consistently indicated TG to be a risk factor for the development of atherosclerosis. To our knowledge this is the first study to determine the relation between FMD and WC, which is used as a parameter of obesity in childhood.

Citing Articles

The Economic Impact of Obesity in Turkey: A Micro-Costing Analysis.

Yavuz D, Akhtar O, Low K, Gras A, Gurser B, Safak Yilmaz E Clinicoecon Outcomes Res. 2024; 16:123-132.

PMID: 38476579 PMC: 10929251. DOI: 10.2147/CEOR.S446560.

Vascular Alterations Preceding Arterial Wall Thickening in Overweight and Obese Children.

Kim S, Park K, Woo S, Kim Y, Lim H, Park W J Clin Med. 2022; 11(12).

PMID: 35743590 PMC: 9224712. DOI: 10.3390/jcm11123520.

Determinants of Intima-Media Thickness in the Young: The ALSPAC Study.

Chiesa S, Charakida M, Georgiopoulos G, Dangardt F, Wade K, Rapala A JACC Cardiovasc Imaging. 2019; 14(2):468-478.

PMID: 31607674 PMC: 7851110. DOI: 10.1016/j.jcmg.2019.08.026.

Exercise and Arterial Modulation in Children: The EXAMIN YOUTH Study.

Endes K, Kochli S, Zahner L, Hanssen H Front Physiol. 2019; 10:43.

PMID: 30774601 PMC: 6367232. DOI: 10.3389/fphys.2019.00043.

ULTRASONOGRAPHIC MARKERS OF CARDIOVASCULAR DISEASE RISK IN OBESE CHILDREN.

Costa K, Ciampo L, Silva P, Lima J, Martins W, de Almeida C Rev Paul Pediatr. 2018; 36(2):171-175.

PMID: 29617475 PMC: 6038792. DOI: 10.1590/1984-0462/;2018;36;2;00016.

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