Mitochondrial Encephalomyopathy--two Years Follow-up by MRI

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 1991 Jan 1

PMID 2047169

Citations 1

Authors

K A Hausegger

M M Millner

F Ebner

F Fluckiger

E Justich

Affiliations

Soon will be listed here.

Abstract

A case of mitochondrial encephalomyopathy (MEM) followed-up by MRI for 2 1/2 y is presented. MRI showed gross, diffusely distributed white matter lesions in both hemispheres predominantly in frontal, parietal, temporal and occipital locations a marked ventriculomegaly indicative of cerebral atrophy. Except a slight increase of the cerebral atrophy there were no changes in the follow-up examinations. There are no specific MRI findings in MEM, the diagnosis is established by the synopsis of MRI, laboratory data and muscle biopsy.

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PMID: 8516029 DOI: 10.1007/BF02012397.

References

Taverni N, Dal Pozzo G, Arnetoli G, Zappoli R . Diagnosis and follow-up of mitochondrial encephalomyopathy: CT and MR studies. J Comput Assist Tomogr. 1988; 12(4):696-7. DOI: 10.1097/00004728-198807000-00042. View

Yamamoto T, Beppu H, Tsubaki T . Mitochondrial encephalomyopathy: fluctuating symptoms and CT. Neurology. 1984; 34(11):1456-60. DOI: 10.1212/wnl.34.11.1456. View

Sengers R, STADHOUDERS A, Trijbels J . Mitochondrial myopathies. Clinical, morphological and biochemical aspects. Eur J Pediatr. 1984; 141(4):192-207. DOI: 10.1007/BF00572761. View

Kuriyama M, UMEZAKI H, Fukuda Y, Osame M, Koike K, Tateishi J . Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions. Neurology. 1984; 34(1):72-7. DOI: 10.1212/wnl.34.1.72. View

DiMauro S, Bonilla E, Zeviani M, Nakagawa M, DeVivo D . Mitochondrial myopathies. Ann Neurol. 1985; 17(6):521-38. DOI: 10.1002/ana.410170602. View

Sengers R, Trijbels J, BAKKEREN J, Ruitenbeek W, Janssen A, STADHOUDERS A . Demyelination and disturbed metabolism of pyruvate: a case report. Eur J Pediatr. 1983; 140(2):127-30. DOI: 10.1007/BF00441661. View

Cole A, Kuzniecky R, Karpati G, Carpenter S, Andermann E, Andermann F . Familial myopathy with changes resembling inclusion body myositis and periventricular leucoencephalopathy. A new syndrome. Brain. 1988; 111 ( Pt 5):1025-37. DOI: 10.1093/brain/111.5.1025. View

Morgan-Hughes J, Hayes D, Clark J, Landon D, Swash M, Stark R . Mitochondrial encephalomyopathies: biochemical studies in two cases revealing defects in the respiratory chain. Brain. 1982; 105 (Pt 3):553-82. DOI: 10.1093/brain/105.3.553. View

Ishitsu T, Miike T, Kitano A, Haraguchi Y, Ohtani Y, Matsuda I . Heterogeneous phenotypes of mitochondrial encephalomyopathy in a single kindred. Neurology. 1987; 37(12):1867-9. DOI: 10.1212/wnl.37.12.1867. View

10.

Penner M, Li K, Gebarski S, Allen R . MR imaging of Pelizaeus-Merzbacher disease. J Comput Assist Tomogr. 1987; 11(4):591-3. DOI: 10.1097/00004728-198707000-00006. View

11.

Markesbery W . Lactic acidemia, mitochondrial myopathy, and basal ganglia calcification. Neurology. 1979; 29(7):1057-60. DOI: 10.1212/wnl.29.7.1057. View