Adult Neurogenesis: Integrating Theories and Separating Functions

Overview

Journal Trends Cogn Sci

Date 2010 May 18

PMID 20471301

Citations 127

Authors

James B Aimone

Wei Deng

Fred H Gage

Affiliations

Soon will be listed here.

Abstract

The continuous incorporation of new neurons in the dentate gyrus of the adult hippocampus raises exciting questions about memory and learning, and has inspired new computational models to understand the function of adult neurogenesis. These theoretical approaches suggest distinct roles for new neurons as they slowly integrate into the existing dentate gyrus network: immature adult-born neurons seem to function as pattern integrators of temporally adjacent events, thereby enhancing pattern separation for events separated in time; whereas maturing adult-born neurons possibly contribute to pattern separation by being more amenable to learning new information, leading to dedicated groups of granule cells that respond to experienced environments. We review these hypothesized functions and supporting empirical research and point to new directions for future theoretical efforts.

Citing Articles

Effect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus.

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Chronic chemogenetic activation of hippocampal progenitors enhances adult neurogenesis and modulates anxiety-like behavior and fear extinction learning.

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Exogenous IL-17A Alleviates Social Behavior Deficits and Increases Neurogenesis in a Murine Model of Autism Spectrum Disorders.

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