Towards a Molecular Understanding of the Differential Signals Regulating Alphabeta/gammadelta T Lineage Choice

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2010 May 18

PMID 20471282

Citations 17

Authors

Sang-Yun Lee

Jason Stadanlick

Dietmar J Kappes

David L Wiest

Affiliations

Soon will be listed here.

Abstract

While insights into the molecular processes that specify adoption of the alphabeta and gammadelta fates are beginning to emerge, the basis for control of specification remains highly controversial. This review highlights the current models attempting to explain T lineage commitment. Recent observations support the hypothesis that the T cell receptor (TCR) provides instructive cues through differences in TCR signaling intensity and/or longevity. Accordingly, we review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates.

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