Neurocognitive Performance in Children with ADHD and OCD

Overview

Journal J Abnorm Child Psychol

Publisher Springer

Date 2010 May 15

PMID 20467805

Citations 22

Authors

Timo D Vloet

Ivo Marx

Berrak Kahraman-Lanzerath

Florian D Zepf

Beate Herpertz-Dahlmann

Kerstin Konrad

Affiliations

Soon will be listed here.

Abstract

Attention-deficit/hyperactivity Disorder (ADHD) and obsessive-compulsive disorder (OCD) have both been linked to dysfunction in the cortico-striato-thalamo-cortical circuitry (CSTCC). However, the exact nature of neurocognitive deficits remains to be investigated in both disorders. We applied two neuropsychological tasks that tap into different functions associated with the CSTCC, namely a serial reaction time (SRT) task, developed to assess implicit sequence learning, and a delay aversion (DA) task in order to assess abnormal motivational processes. The performance data of boys with ADHD (n=20), OCD (n=20) and healthy controls (n=25), all aged 10-18 years, were compared. Subjects with ADHD less frequently chose the larger, more delayed reward compared to those with OCD and controls, while subjects with OCD showed impaired implicit learning. In contrast, the ADHD group was unimpaired in their implicit learning behavior and the OCD group was not characterized by a DA style. Within the OCD-group, severity of obsessions was associated with implicit learning deficits and impulsive symptoms with DA in the ADHD-group. This double dissociation highlights the distinct cognitive dysfunctions associated with ADHD and OCD and might possibly point to different neural abnormalities in both disorders.

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References

Sonuga-Barke E . Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry. 2005; 57(11):1231-8. DOI: 10.1016/j.biopsych.2004.09.008. View

Goldman B, Martin E, Calamari J, Woodard J, Chik H, Messina M . Implicit learning, thought-focused attention and obsessive-compulsive disorder: a replication and extension. Behav Res Ther. 2007; 46(1):48-61. DOI: 10.1016/j.brat.2007.10.004. View

Sonuga-Barke E, Taylor E, Sembi S, Smith J . Hyperactivity and delay aversion--I. The effect of delay on choice. J Child Psychol Psychiatry. 1992; 33(2):387-98. DOI: 10.1111/j.1469-7610.1992.tb00874.x. View

Sonuga-Barke E, Sergeant J, Nigg J, Willcutt E . Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications. Child Adolesc Psychiatr Clin N Am. 2008; 17(2):367-84, ix. DOI: 10.1016/j.chc.2007.11.008. View

Sonuga-Barke E . The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics. Neurosci Biobehav Rev. 2003; 27(7):593-604. DOI: 10.1016/j.neubiorev.2003.08.005. View

Marker C, Calamari J, Woodard J, Riemann B . Cognitive self-consciousness, implicit learning and obsessive-compulsive disorder. J Anxiety Disord. 2005; 20(4):389-407. DOI: 10.1016/j.janxdis.2005.03.003. View

Rauch S . Neuroimaging and neurocircuitry models pertaining to the neurosurgical treatment of psychiatric disorders. Neurosurg Clin N Am. 2003; 14(2):213-23, vii-viii. DOI: 10.1016/s1042-3680(02)00114-6. View

Thomas K, Nelson C . Serial reaction time learning in preschool- and school-age children. J Exp Child Psychol. 2001; 79(4):364-87. DOI: 10.1006/jecp.2000.2613. View

Goodman W, Price L, Rasmussen S, Mazure C, Delgado P, Heninger G . The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry. 1989; 46(11):1012-6. DOI: 10.1001/archpsyc.1989.01810110054008. View

10.

Rauch S, Wedig M, Wright C, Martis B, McMullin K, Shin L . Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder. Biol Psychiatry. 2006; 61(3):330-6. DOI: 10.1016/j.biopsych.2005.12.012. View

11.

Bitsakou P, Psychogiou L, Thompson M, Sonuga-Barke E . Delay Aversion in Attention Deficit/Hyperactivity Disorder: an empirical investigation of the broader phenotype. Neuropsychologia. 2008; 47(2):446-56. DOI: 10.1016/j.neuropsychologia.2008.09.015. View

12.

Maia T, Cooney R, Peterson B . The neural bases of obsessive-compulsive disorder in children and adults. Dev Psychopathol. 2008; 20(4):1251-83. PMC: 3079445. DOI: 10.1017/S0954579408000606. View

13.

MacMaster F, ONeill J, Rosenberg D . Brain imaging in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2008; 47(11):1262-72. PMC: 2696312. DOI: 10.1097/CHI.0b013e318185d2be. View

14.

Dalen L, Sonuga-Barke E, Hall M, Remington B . Inhibitory deficits, delay aversion and preschool AD/HD: implications for the dual pathway model. Neural Plast. 2004; 11(1-2):1-11. PMC: 2565443. DOI: 10.1155/np.2004.1. View

15.

Breuer D, Wolff Metternich T, Dopfner M . [The assessment of Attention Deficit Hyperactivity Disorder (ADHD) by teacher ratings - validity and reliability of the FBB-HKS]. Z Kinder Jugendpsychiatr Psychother. 2009; 37(5):431-40. DOI: 10.1024/1422-4917.37.5.431. View

16.

Savage C, Rauch S . Cognitive deficits in obsessive-compulsive disorder. Am J Psychiatry. 2000; 157(7):1182-3. DOI: 10.1176/appi.ajp.157.7.1182. View

17.

Goodman W, Price L, Rasmussen S, Mazure C, Fleischmann R, Hill C . The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989; 46(11):1006-11. DOI: 10.1001/archpsyc.1989.01810110048007. View

18.

Castellanos F, Sonuga-Barke E, Milham M, Tannock R . Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci. 2006; 10(3):117-23. DOI: 10.1016/j.tics.2006.01.011. View

19.

Leckman J . Tourette's syndrome. Lancet. 2002; 360(9345):1577-86. DOI: 10.1016/S0140-6736(02)11526-1. View

20.

Chamberlain S, Blackwell A, Fineberg N, Robbins T, Sahakian B . The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev. 2005; 29(3):399-419. DOI: 10.1016/j.neubiorev.2004.11.006. View