Acquisition of an Active Avoidance Reaction in Rats and Morphological Changes in the Hippocampus in Pentylenetetrazol Kindling

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 2010 May 14

PMID 20464515

Citations 2

Authors

T V Pavlova

M Y Stepanichev

A B Gekht

N V Gulyaeva

Affiliations

Soon will be listed here.

Abstract

The relationship between measures of active avoidance behavior and morphological changes in the hippocampus was studied in rats after kindling induced by administration of pentylenetetrazol. Pentylenetetrazol kindling impaired the acquisition of the avoidance reaction and increased the number of intersignal reactions without altering the acquisition of the avoidance reaction in the shuttle box in rats. The numbers of neurons in the hippocampus (fields CA1 and CA3) and dentate fascia decreased, while the numbers of damaged neurons increased. Inverse correlations between seizure severity and the numbers of neurons in hippocampal fields CA1 and CA3 and the dentate fascia were seen in rats subjected to kindling. Rats of this group also showed positive correlations between seizure severity and the numbers of damaged neurons in field CA1 and the dentate fascia. There were no correlations between measures of convulsive activity or the number of cells in hippocampal zones and measures of the acquired avoidance behavior. Control animals showed negative correlations between the numbers of damaged cells in field CA1 and the dentate fascia and the characteristics of avoidance behavior in the first and third training sessions.

Citing Articles

Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain.

Kahne T, Richter S, Kolodziej A, Smalla K, Pielot R, Engler A J Neurochem. 2016; 138(1):124-38.

PMID: 27062398 PMC: 5089584. DOI: 10.1111/jnc.13636.

Synaptic proteome changes in mouse brain regions upon auditory discrimination learning.

Kahne T, Kolodziej A, Smalla K, Eisenschmidt E, Haus U, Weismantel R Proteomics. 2012; 12(15-16):2433-44.

PMID: 22696468 PMC: 3509369. DOI: 10.1002/pmic.201100669.

References

Cavazos J, Sutula T . Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Brain Res. 1990; 527(1):1-6. DOI: 10.1016/0006-8993(90)91054-k. View

Myhrer T . Locomotor, avoidance,and maze behavior in rats with selective disruption of hippocampal output. J Comp Physiol Psychol. 1975; 89(7):759-77. DOI: 10.1037/h0077051. View

Pavlova T, Iakovlev A, Stepanichev M, Mendzheritskii A, Guliaeva N . [Pentylenetetrazole kindling induces caspase-3 activation in rat brain]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2003; 53(1):110-2. View

Vogt K, Nicoll R . Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proc Natl Acad Sci U S A. 1999; 96(3):1118-22. PMC: 15360. DOI: 10.1073/pnas.96.3.1118. View

Buzsaki G . Feed-forward inhibition in the hippocampal formation. Prog Neurobiol. 1984; 22(2):131-53. DOI: 10.1016/0301-0082(84)90023-6. View

Mason C, Cooper R . A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazol. Epilepsia. 1972; 13(5):663-74. DOI: 10.1111/j.1528-1157.1972.tb04401.x. View

Szyndler J, Rok P, Maciejak P, Walkowiak J, Czlonkowska A, Sienkiewicz-Jarosz H . Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems. Pharmacol Biochem Behav. 2002; 73(4):851-61. DOI: 10.1016/s0091-3057(02)00912-7. View

GODDARD G, McIntyre D, Leech C . A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol. 1969; 25(3):295-330. DOI: 10.1016/0014-4886(69)90128-9. View

Franke H, Kittner H . Morphological alterations of neurons and astrocytes and changes in emotional behavior in pentylenetetrazol-kindled rats. Pharmacol Biochem Behav. 2001; 70(2-3):291-303. DOI: 10.1016/s0091-3057(01)00612-8. View

10.

Becker A, Grecksch G, Ruthrich H, Pohle W, Marx B, Matthies H . Kindling and its consequences on learning in rats. Behav Neural Biol. 1992; 57(1):37-43. DOI: 10.1016/0163-1047(92)90735-m. View

11.

ORourke D, Saykin A, Gilhool J, Harley R, OConnor M, Sperling M . Unilateral hemispheric memory and hippocampal neuronal density in temporal lobe epilepsy. Neurosurgery. 1993; 32(4):574-80; discussion 580-1. DOI: 10.1227/00006123-199304000-00013. View

12.

Armstrong D . Epilepsy-induced microarchitectural changes in the brain. Pediatr Dev Pathol. 2005; 8(6):607-14. DOI: 10.1007/s10024-005-0054-3. View

13.

. Pentylenetetrazole kindling impairs long-term memory in rats. Eur Neuropsychopharmacol. 1995; 5(1):53-6. DOI: 10.1016/0924-977x(94)00134-w. View

14.

Rauca C, Pohle W, Grunenberg K, Franze S . Hypothermia inhibits pentylenetetrazol kindling and prevents kindling-induced deficit in shuttle-box avoidance. Pharmacol Biochem Behav. 2000; 65(1):23-30. DOI: 10.1016/s0091-3057(99)00132-x. View

15.

Becker A, Tiedge A, Grecksch G . Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss. Pharmacol Res. 1997; 35(1):27-32. DOI: 10.1006/phrs.1996.0116. View

16.

Mortazavi F, Ericson M, Story D, Hulce V, Dunbar G . Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. Epilepsy Behav. 2005; 7(4):629-38. DOI: 10.1016/j.yebeh.2005.08.019. View

17.

JARRARD L . Anatomical and behavioral analysis of hippocampal cell fields in rats. J Comp Physiol Psychol. 1976; 90(11):1035-50. DOI: 10.1037/h0078659. View

18.

Briellmann R, Newton M, Wellard R, Jackson G . Hippocampal sclerosis following brief generalized seizures in adulthood. Neurology. 2001; 57(2):315-7. DOI: 10.1212/wnl.57.2.315. View

19.

Kalynchuk L, Davis A, Gregus A, Taggart J, Chris Dodd C, Wintink A . Hippocampal involvement in the expression of kindling-induced fear in rats. Neurosci Biobehav Rev. 2002; 25(7-8):687-96. DOI: 10.1016/s0149-7634(01)00051-3. View

20.

Cavazos J, Das I, Sutula T . Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci. 1994; 14(5 Pt 2):3106-21. PMC: 6577461. View