Fatigue in Primary Biliary Cirrhosis

Overview

Journal Nat Rev Gastroenterol Hepatol

Specialty Gastroenterology

Date 2010 May 12

PMID 20458334

Citations 19

Authors

Ghulam Abbas

Roberta A Jorgensen

Keith D Lindor

Affiliations

Soon will be listed here.

Abstract

Primary biliary cirrhosis (PBC) is a chronic, autoimmune, cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis of the liver and may need liver transplantation in the late stage of disease. Fatigue and pruritus are the most common symptoms of PBC, but the majority of patients are asymptomatic at first presentation. There is no specific treatment for fatigue in PBC, but modafinil has shown some potential beneficial effects, such as increased energy levels and decreased total sleep time. This Review article discusses the natural history and the measurement of fatigue in patients with PBC. The central and the peripheral mechanisms that have been suggested for the pathogenesis of fatigue in PBC are also discussed and treatment options are reviewed.

Citing Articles

Psychological factors and biochemical indicators influencing sleep disturbance of patients with primary biliary cholangitis in China: a cross-sectional survey analysis.

Zhao C, Zang B, Liu Q, Liu B, Yao Y, Li H Front Med (Lausanne). 2024; 11:1444473.

PMID: 39430587 PMC: 11488817. DOI: 10.3389/fmed.2024.1444473.

Neuroimmune modulation in liver pathophysiology.

Zou J, Li J, Wang X, Tang D, Chen R J Neuroinflammation. 2024; 21(1):188.

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Management of fatigue and sleep disorders in patients with chronic liver disease.

Niezen S, Noll A, Bamporiki J, Rogal S Clin Liver Dis (Hoboken). 2024; 23(1):e0122.

PMID: 38911999 PMC: 11191865. DOI: 10.1097/CLD.0000000000000122.

Evolutionary relationship between antimitochondrial antibody positivity and primary biliary cholangitis in Taiwan: a 16-year hospital cohort study.

Chang M, Cheng J, Le P, Chen W, Ku H, Chien R Therap Adv Gastroenterol. 2024; 17:17562848241241227.

PMID: 38560427 PMC: 10981211. DOI: 10.1177/17562848241241227.

High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.

Bager P, Bossen L, Gantzel R, Gronbaek H PLoS One. 2024; 19(3):e0301354.

PMID: 38551983 PMC: 10980237. DOI: 10.1371/journal.pone.0301354.

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