Autologous Conditioned Plasma As Therapy of Tendon and Ligament Lesions in Seven Horses

Overview

Journal J Vet Sci

Specialty Veterinary Medicine

Date 2010 May 12

PMID 20458161

Citations 13

Authors

Rindermann Georg

Cislakova Maria

Arndt Gisela

Carstanjen Bianca

Affiliations

Soon will be listed here.

Abstract

This case report describes the intralesional application of autologous conditioned plasma (ACP) in seven horses as treatment of severe tendinitis of the superficial digital flexor tendon, deep digital flexor tendon, or desmitis of the inferior check ligament. Follow-up data of the horses revealed a positive outcome in 10 to 13 months post injury. All horses treated with ACP were either performing in their previous work-load or were back in full training. Further studies with long-term follow-up will have to be performed to support these clinical intermediate-term observations.

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References

Schnabel L, Mohammed H, Miller B, McDermott W, Jacobson M, Santangelo K . Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res. 2006; 25(2):230-40. DOI: 10.1002/jor.20278. View

Dyson P, Jackson B, Pfeiffer D, Price J . Days lost from training by two- and three-year-old Thoroughbred horses: a survey of seven UK training yards. Equine Vet J. 2009; 40(7):650-7. DOI: 10.2746/042516408x363242. View

Rossdale P, Hopes R, Digby N, Offord K . Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec. 1985; 116(3):66-9. DOI: 10.1136/vr.116.3.66. View

Fortier L, Smith R . Regenerative medicine for tendinous and ligamentous injuries of sport horses. Vet Clin North Am Equine Pract. 2008; 24(1):191-201. DOI: 10.1016/j.cveq.2007.11.002. View

Bosch G, van Schie H, de Groot M, Cadby J, van de Lest C, Barneveld A . Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study. J Orthop Res. 2009; 28(2):211-7. DOI: 10.1002/jor.20980. View

de Mos M, Windt A, Jahr H, van Schie H, Weinans H, Verhaar J . Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med. 2008; 36(6):1171-8. DOI: 10.1177/0363546508314430. View

Arguelles D, Carmona J, Climent F, Munoz E, Prades M . Autologous platelet concentrates as a treatment for musculoskeletal lesions in five horses. Vet Rec. 2008; 162(7):208-11. DOI: 10.1136/vr.162.7.208. View

Appel T, Potzsch B, Muller J, von Lindern J, Berge S, Reich R . Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Implants Res. 2002; 13(5):522-8. DOI: 10.1034/j.1600-0501.2002.130512.x. View

Lam K, Parkin T, Riggs C, Morgan K . Descriptive analysis of retirement of Thoroughbred racehorses due to tendon injuries at the Hong Kong Jockey Club (1992-2004). Equine Vet J. 2007; 39(2):143-8. DOI: 10.2746/042516407x159132. View

10.

Sutter W, Kaneps A, Bertone A . Comparison of hematologic values and transforming growth factor-beta and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am J Vet Res. 2004; 65(7):924-30. DOI: 10.2460/ajvr.2004.65.924. View

11.

Marx R . Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004; 62(4):489-96. DOI: 10.1016/j.joms.2003.12.003. View

12.

Pietrzak W, Eppley B . Platelet rich plasma: biology and new technology. J Craniofac Surg. 2005; 16(6):1043-54. DOI: 10.1097/01.scs.0000186454.07097.bf. View

13.

Perkins N, Reid S, Morris R . Profiling the New Zealand Thoroughbred racing industry. 2. Conditions interfering with training and racing. N Z Vet J. 2005; 53(1):69-76. DOI: 10.1080/00480169.2005.36471. View

14.

Reef V . Superficial digital flexor tendon healing: ultrasonographic evaluation of therapies. Vet Clin North Am Equine Pract. 2001; 17(1):159-78, vii-viii. DOI: 10.1016/s0749-0739(17)30081-0. View