Neuronal Generator Patterns of Olfactory Event-related Brain Potentials in Schizophrenia

Overview

Journal Psychophysiology

Specialty Psychiatry

Date 2010 May 12

PMID 20456657

Citations 7

Authors

Jurgen Kayser

Craig E Tenke

Dolores Malaspina

Christopher J Kroppmann

Jennifer D Schaller

Andrew Deptula

Nathan A Gates

Jill M Harkavy-Friedman

Roberto Gil

Gerard E Bruder

Affiliations

Soon will be listed here.

Abstract

To better characterize neurophysiologic processes underlying olfactory dysfunction in schizophrenia, nose-referenced 30-channel electroencephalogram was recorded from 32 patients and 35 healthy adults (18 and 18 male) during detection of hydrogen sulfide (constant-flow olfactometer, 200 ms unirhinal exposure). Event-related potentials (ERPs) were transformed to reference-free current source density (CSD) waveforms and analyzed by unrestricted Varimax-PCA. Participants indicated when they perceived a high (10 ppm) or low (50% dilution) odor concentration. Patients and controls did not differ in detection of high (23% misses) and low (43%) intensities and also had similar olfactory ERP waveforms. CSDs showed a greater bilateral frontotemporal N1 sink (305 ms) and mid-parietal P2 source (630 ms) for high than low intensities. N1 sink and P2 source were markedly reduced in patients for high intensity stimuli, providing further neurophysiological evidence of olfactory dysfunction in schizophrenia.

Citing Articles

Assessment and Scientific Progresses in the Analysis of Olfactory Evoked Potentials.

Arpaia P, Cataldo A, Criscuolo S, De Benedetto E, Masciullo A, Schiavoni R Bioengineering (Basel). 2022; 9(6).

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Unpleasant Odors Affect Alerting Attention in Young Men: An Event-Related Potential Study Using the Attention Network Test.

Zhang M, Gong X, Jia J, Wang X Front Neurosci. 2021; 15:781997.

PMID: 34949985 PMC: 8688710. DOI: 10.3389/fnins.2021.781997.

Electrophysiological correlates of top-down attentional modulation in olfaction.

Singh A, Touhara K, Okamoto M Sci Rep. 2019; 9(1):4953.

PMID: 30894641 PMC: 6426950. DOI: 10.1038/s41598-019-41319-6.

Potential Role of OERP as Early Marker of Mild Cognitive Impairment.

Invitto S, Piraino G, Ciccarese V, Carmillo L, Caggiula M, Trianni G Front Aging Neurosci. 2018; 10:272.

PMID: 30271339 PMC: 6146232. DOI: 10.3389/fnagi.2018.00272.

The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.

Kamarajan C, Pandey A, Chorlian D, Porjesz B Int J Psychophysiol. 2014; 97(3):310-22.

PMID: 25448264 PMC: 4422780. DOI: 10.1016/j.ijpsycho.2014.10.013.

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