Immune Modulation of Co-transplantation Mesenchymal Stem Cells with Islet on T and Dendritic Cells

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2010 May 12

PMID 20456412

Citations 29

Authors

F R Li

X G Wang

C Y Deng

H Qi

L L Ren

H X Zhou

Affiliations

Soon will be listed here.

Abstract

Allogeneic pancreatic islet transplantation theoretically represents a cure for type 1 diabetes. However, current immune suppressive therapies are often associated with undesired side effects. Given this problem, and the shortage of human islet donors, the majority of type 1 diabetes patients cannot currently be offered an islet transplant. However, it has been found that mesenchymal stem cells (MSCs) could exert unique immunosuppressive effects both in vitro and in vivo. Herein we transplanted allogeneic 200 islets alone or in combination with MSCs (3 x 10(6) cells) under the kidney capsules of diabetic C57LB/6 mouse. We found that the ratios of T helper type 1 (Th1) to Th2 and Tc1 to Tc2 were reduced, and the numbers of naive and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis and interleukin-12 secretion of dendritic cell (DCs)-derived bone marrow cells (BMCs) from receptor mice were suppressed. Rejection reaction was alleviated by MSCs which exerted suppressive effects through T lymphocyte subsets and DCs.

Citing Articles

Advancements and Challenges in Immune Protection Strategies for Islet Transplantation.

Wang X, Zeng Z, Li D, Wang K, Zhang W, Yu Y J Diabetes. 2025; 17(1):e70048.

PMID: 39829227 PMC: 11744047. DOI: 10.1111/1753-0407.70048.

Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis.

Li M, Li J, Wang Y, Jiang G, Jiang H, Li M Stem Cell Res Ther. 2024; 15(1):475.

PMID: 39696548 PMC: 11657361. DOI: 10.1186/s13287-024-04091-7.

Immunoprotection Strategies in β-Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation.

Grimus S, Sarangova V, Welzel P, Ludwig B, Seissler J, Kemter E Adv Sci (Weinh). 2024; 11(31):e2401385.

PMID: 38884159 PMC: 11336975. DOI: 10.1002/advs.202401385.

Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives.

Miceli V, Bulati M, Gallo A, Iannolo G, Busa R, Conaldi P Biomedicines. 2023; 11(3).

PMID: 36979668 PMC: 10045387. DOI: 10.3390/biomedicines11030689.

Adipose-derived stem cells regulate CD4+ T-cell-mediated macrophage polarization and fibrosis in fat grafting in a mouse model.

Chen X, Chen Y, Wang Z, Dong Z, Yao Y, Li Y Heliyon. 2022; 8(11):e11538.

PMID: 36406697 PMC: 9672326. DOI: 10.1016/j.heliyon.2022.e11538.

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