Posttraumatic Stress Disorder and the Genetic Structure of Comorbidity

Overview

Journal J Abnorm Psychol

Publisher American Psychological Association

Specialty Psychology

Date 2010 May 12

PMID 20455605

Citations 63

Authors

Erika J Wolf

Mark W Miller

Robert F Krueger

Michael J Lyons

Ming T Tsuang

Karestan C Koenen

Affiliations

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Abstract

This study used structural equation modeling to examine the genetic and environmental architecture of latent dimensions of internalizing and externalizing psychiatric comorbidity and explored structural associations between posttraumatic stress disorder (PTSD) and these dimensions. Data were drawn from the Vietnam Era Twin Registry and included lifetime diagnoses for PTSD and a range of other psychiatric disorders for 3,372 male-male twin pairs. Examination of the phenotypic structure of these disorders revealed that PTSD cross-loaded on both Internalizing and Externalizing common factors. Biometric analyses suggested largely distinct genetic risk factors for the latent internalizing and externalizing comorbidity dimensions, with the total heritability of the Externalizing factor (69%) estimated to be significantly stronger than that for Internalizing (41%). Nonshared environment explained the majority of the remaining variance in the Internalizing (58%) and Externalizing (20%) factors. Shared genetic variance across the 2 dimensions explained 67% of their phenotypic correlation (r = .52). These findings have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology.

Citing Articles

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