Periodontal Bacteria and Hypertension: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)

Overview

Journal J Hypertens

Specialty Cardiology & Vascular Diseases

Date 2010 May 11

PMID 20453665

Citations 87

Authors

Moise Desvarieux

Ryan T Demmer

David R Jacobs Jr

Tatjana Rundek

Bernadette Boden-Albala

Ralph L Sacco

Panos N Papapanou

Affiliations

Soon will be listed here.

Abstract

Objective: Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension.

Methods And Results: Six hundred and fifty-three dentate men and women with no history of stroke or myocardial infarction were enrolled in INVEST. We collected 4533 subgingival plaque samples (average of seven samples per participant). These were quantitatively assessed for 11 periodontal bacteria using DNA-DNA checkerboard hybridization. Cardiovascular risk factor measurements were obtained. Blood pressure and hypertension (SBP > or =140 mmHg, DBP > or =90 mmHg or taking antihypertensive medication, or self-reported history) were each regressed on the level of bacteria: considered causative of periodontal disease (etiologic bacterial burden); associated with periodontal disease (putative bacterial burden); and associated with periodontal health (health-associated bacterial burden). All analyses were adjusted for age, race/ethnicity, sex, education, BMI, smoking, diabetes, low-density lipoprotein and high-density lipoprotein cholesterol. Etiologic bacterial burden was positively associated with both blood pressure and prevalent hypertension. Comparing the highest and lowest tertiles of etiologic bacterial burden, SBP was 9 mmHg higher, DBP was 5 mmHg higher (P for linear trend was less than 0.001 in each case), and the odds ratio for prevalent hypertension was 3.05 (95% confidence interval 1.60-5.82) after multivariable adjustment.

Conclusion: Our data provide evidence of a direct relationship between the levels of subgingival periodontal bacteria and both SBP and DBP as well as hypertension prevalence.

Citing Articles

The association between the oral microbiome and hypertension: a systematic review.

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PMID: 39902217 PMC: 11789219. DOI: 10.1080/20002297.2025.2459919.

Periodontal pathogens and obesity in the context of cardiovascular risks across age groups.

Leonov G, Varaeva Y, Livantsova E, Vasilyev A, Vladimirskaya O, Korotkova T Front Oral Health. 2025; 5():1488833.

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The Oral-Gut-Brain Axis: The Influence of Microbes as a Link of Periodontitis With Ischemic Stroke.

Zhong Y, Kang X, Bai X, Pu B, Smerin D, Zhao L CNS Neurosci Ther. 2024; 30(12):e70152.

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Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS).

Molinsky R, Johnson A, Marotz L, Roy S, Bohn B, Goh C J Clin Periodontol. 2024; 52(1):2-15.

PMID: 39394967 PMC: 11671169. DOI: 10.1111/jcpe.14067.

Association between Periodontitis and Hypertension among Adult Population in Rwanda.

Gatarayiha A, Brookes Z, Rulisa S, Andegiorgish A, Mutesa L J Clin Med. 2024; 13(16).

PMID: 39200864 PMC: 11355554. DOI: 10.3390/jcm13164722.

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