Regulation of SIRT1 in Cellular Functions: Role of Polyphenols

Overview

Journal Arch Biochem Biophys

Publisher Elsevier

Specialties Biochemistry
Biophysics

Date 2010 May 11

PMID 20450879

Citations 254

Authors

Sangwoon Chung

Hongwei Yao

Samuel Caito

Jae-Woong Hwang

Gnanapragasam Arunachalam

Irfan Rahman

Affiliations

Soon will be listed here.

Abstract

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging, inflammation-immune function, endothelial functions, and circadian rhythms. Naturally occurring dietary polyphenols, such as resveratrol, curcumin, quercetin, and catechins, have antioxidant and anti-inflammatory properties via modulating different pathways, such as NF-kappaB- and mitogen activated protein kinase-dependent signaling pathways. In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models. Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction. In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli.

Citing Articles

37 kDa LRP::FLAG enhances telomerase activity and reduces ageing markers in vivo.

Otgaar T, Bernert M, Morris G, Baichan P, Bignoux M, Letsolo B Cell Mol Life Sci. 2025; 82(1):83.

PMID: 39985566 PMC: 11846807. DOI: 10.1007/s00018-025-05593-0.

Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).

Zheng S, Yang L, Dai Q, Li X, Masuoka T, Lv J Biomed Rep. 2025; 22(3):46.

PMID: 39882335 PMC: 11775641. DOI: 10.3892/br.2025.1924.

The Application of Olive-Derived Polyphenols on Exercise-Induced Inflammation: A Scoping Review.

Lillis J, Willmott A, Chichger H, Roberts J Nutrients. 2025; 17(2).

PMID: 39861354 PMC: 11767577. DOI: 10.3390/nu17020223.

Mechanism of Sirtuin1-Mediated Deacetylation of p65-Mediated Ferroptosis of Hippocampal Neurons in Cerebral Injury after Cardiopulmonary Resuscitation in Rats.

Min X, Shi Y, Xu Y, Li Y, Dong Y, Chen F Neurochem Res. 2025; 50(1):66.

PMID: 39751951 DOI: 10.1007/s11064-024-04297-4.

Relationship between timing of coffee and tea consumption with mortality (total, cardiovascular disease and diabetes) in people with diabetes: the U.S. National Health and Nutrition Examination Survey, 2003-2014.

Yang R, Lei Q, Liu Z, Shan X, Han S, Tang Y BMC Med. 2024; 22(1):526.

PMID: 39523296 PMC: 11552133. DOI: 10.1186/s12916-024-03736-x.

References

Beher D, Wu J, Cumine S, Kim K, Lu S, Atangan L . Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des. 2009; 74(6):619-24. DOI: 10.1111/j.1747-0285.2009.00901.x. View

Zhang R, Chen H, Liu J, Jia Y, Zhang Z, Yang R . SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem. 2010; 285(10):7097-110. PMC: 2844159. DOI: 10.1074/jbc.M109.038604. View

Milne J, Lambert P, Schenk S, Carney D, Smith J, Gagne D . Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007; 450(7170):712-6. PMC: 2753457. DOI: 10.1038/nature06261. View

Argmann C, Auwerx J . Insulin secretion: SIRT4 gets in on the act. Cell. 2006; 126(5):837-9. DOI: 10.1016/j.cell.2006.08.031. View

Tang B, Chua C . Is systemic activation of Sirt1 beneficial for ageing-associated metabolic disorders?. Biochem Biophys Res Commun. 2009; 391(1):6-10. DOI: 10.1016/j.bbrc.2009.11.016. View

Ginkel P, Sareen D, Subramanian L, Walker Q, Darjatmoko S, Lindstrom M . Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin Cancer Res. 2007; 13(17):5162-9. DOI: 10.1158/1078-0432.CCR-07-0347. View

Leiro J, Arranz J, Fraiz N, Sanmartin M, Quezada E, Orallo F . Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling. Int Immunopharmacol. 2005; 5(2):393-406. DOI: 10.1016/j.intimp.2004.10.006. View

Davis J, Murphy E, Carmichael M, Davis B . Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009; 296(4):R1071-7. DOI: 10.1152/ajpregu.90925.2008. View

Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S . Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem. 2010; 285(11):8375-82. PMC: 2832987. DOI: 10.1074/jbc.M109.090266. View

10.

van der Horst A, Tertoolen L, de Vries-Smits L, Frye R, Medema R, Burgering B . FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem. 2004; 279(28):28873-9. DOI: 10.1074/jbc.M401138200. View

11.

Fulco M, Cen Y, Zhao P, Hoffman E, McBurney M, Sauve A . Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell. 2008; 14(5):661-73. PMC: 2431467. DOI: 10.1016/j.devcel.2008.02.004. View

12.

Shin S, Cho I, Kim S . Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. Mol Pharmacol. 2009; 76(4):884-95. DOI: 10.1124/mol.109.058479. View

13.

Loke W, Proudfoot J, Hodgson J, McKinley A, Hime N, Magat M . Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2010; 30(4):749-57. DOI: 10.1161/ATVBAHA.109.199687. View

14.

Sulaiman M, Matta M, Sunderesan N, Gupta M, Periasamy M, Gupta M . Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2009; 298(3):H833-43. PMC: 2838561. DOI: 10.1152/ajpheart.00418.2009. View

15.

Wyke S, Russell S, Tisdale M . Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation. Br J Cancer. 2004; 91(9):1742-50. PMC: 2409951. DOI: 10.1038/sj.bjc.6602165. View

16.

Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F . SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2):317-28. DOI: 10.1016/j.cell.2008.06.050. View

17.

Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto J, Bagi Z, Ballabh P . Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009; 297(5):H1876-81. PMC: 2781360. DOI: 10.1152/ajpheart.00375.2009. View

18.

Penumathsa S, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R . Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol. 2006; 42(3):508-16. PMC: 1857339. DOI: 10.1016/j.yjmcc.2006.10.018. View

19.

Yang J, Kong X, Martins-Santos M, Aleman G, Chaco E, Liu G . Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. J Biol Chem. 2009; 284(40):27042-53. PMC: 2785634. DOI: 10.1074/jbc.M109.047340. View

20.

Gao Z, Ye J . Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun. 2008; 376(4):793-6. PMC: 2629791. DOI: 10.1016/j.bbrc.2008.09.079. View