» Articles » PMID: 20444740

Hypoxic Regulation of Erythropoiesis and Iron Metabolism

Overview
Specialties Nephrology
Physiology
Date 2010 May 7
PMID 20444740
Citations 136
Authors
Affiliations
Soon will be listed here.
Abstract

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.

Citing Articles

L-Arginine and Nitric Oxide in Vascular Regulation-Experimental Findings in the Context of Blood Donation.

Kurhaluk N, Tkaczenko H Nutrients. 2025; 17(4).

PMID: 40004994 PMC: 11858268. DOI: 10.3390/nu17040665.


Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.

Johnson N, Dickenson J, MacKenzie B, Isakovich R, Kalker A, Bouten J Proc Natl Acad Sci U S A. 2025; 122(1):e2412561121.

PMID: 39793031 PMC: 11725942. DOI: 10.1073/pnas.2412561121.


Anemia and Mineral Bone Disorder in Kidney Disease Patients: The Role of FGF-23 and Other Related Factors.

Carullo N, Sorbo D, Faga T, Pugliese S, Zicarelli M, Costa D Int J Mol Sci. 2024; 25(23).

PMID: 39684548 PMC: 11641783. DOI: 10.3390/ijms252312838.


Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1.

Kang G, Kim Y, Oh H, Jo H, Bok S, Jeon Y Lab Anim Res. 2024; 40(1):37.

PMID: 39473019 PMC: 11523771. DOI: 10.1186/s42826-024-00224-4.


Acute exposure to carbon monoxide inhalation and/or hot water immersion transiently increases erythropoietin in females but not in males.

DiMarco K, Chapman C, Weiser N, Matsell E, Lucernoni K, Chacon S Exp Physiol. 2024; 109(10):1782-1795.

PMID: 39143855 PMC: 11442759. DOI: 10.1113/EP091923.


References
1.
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth M . Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009; 41(4):478-81. DOI: 10.1038/ng.320. View

2.
Ravi R, Mookerjee B, Bhujwalla Z, Sutter C, Artemov D, Zeng Q . Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 2000; 14(1):34-44. PMC: 316350. View

3.
Besarab A, Frinak S, Yee J . What is so bad about a hemoglobin level of 12 to 13 g/dL for chronic kidney disease patients anyway?. Adv Chronic Kidney Dis. 2009; 16(2):131-42. DOI: 10.1053/j.ackd.2008.12.007. View

4.
Galson D, Tsuchiya T, TENDLER D, Huang L, Ren Y, Ogura T . The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol. 1995; 15(4):2135-44. PMC: 230441. DOI: 10.1128/MCB.15.4.2135. View

5.
Percy M, McMullin M, Jowitt S, Potter M, Treacy M, Watson W . Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry. Blood. 2003; 102(3):1097-9. DOI: 10.1182/blood-2002-10-3246. View