Atypical Functional Brain Activation During a Multiple Object Tracking Task in Girls with Turner Syndrome: Neurocorrelates of Reduced Spatiotemporal Resolution

Overview

Journal Am J Intellect Dev Disabil

Specialty Psychiatry

Date 2010 May 6

PMID 20441384

Citations 12

Authors

Elliott A Beaton

Joel Stoddard

Song Lai

John Lackey

Jianrong Shi

Judith L Ross

Tony J Simon

Affiliations

Soon will be listed here.

Abstract

Turner syndrome is associated with spatial and numerical cognitive impairments. We hypothesized that these nonverbal cognitive impairments result from limits in spatial and temporal processing, particularly as it affects attention. To examine spatiotemporal attention in girls with Turner syndrome versus typically developing controls, we used a multiple object tracking task during functional magnetic resonance (fMRI) imaging. Participants actively tracked a target among six distracters or passively viewed the animations. Neural activation in girls with Turner syndrome during object tracking overlapped with but was dissimilar to the canonical frontoparietal network evident in typically developing controls and included greater limbic activity. Task performance and atypical functional activation indicate anomalous development of cortical and subcortical temporal and spatial processing circuits in girls with Turner syndrome.

Citing Articles

Using fMRI to Assess Brain Activity in People With Down Syndrome: A Systematic Review.

Carbo-Carrete M, Canete-Masse C, Pero-Cebollero M, Guardia-Olmos J Front Hum Neurosci. 2020; 14:147.

PMID: 32395104 PMC: 7197628. DOI: 10.3389/fnhum.2020.00147.

Altered Brain Structure in Infants with Turner Syndrome.

Davenport M, Cornea E, Xia K, Crowley J, Halvorsen M, Goldman B Cereb Cortex. 2019; 30(2):587-596.

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Clinical developmental, neuropsychological, and social-emotional features of Turner syndrome.

Hutaff-Lee C, Bennett E, Howell S, Tartaglia N Am J Med Genet C Semin Med Genet. 2019; 181(1):126-134.

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Neurocognitive Development of the Resolution of Selective Visuo-Spatial Attention: Functional MRI Evidence From Object Tracking.

Wolf K, Galeano Weber E, van den Bosch J, Volz S, Noth U, Deichmann R Front Psychol. 2018; 9:1106.

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Chiari I Malformation Associated with Turner Syndrome.

Harsha K, Nair J J Neurosci Rural Pract. 2017; 8(2):277-280.

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