Endogenous Neurosteroid Synthesis Modulates Seizure Frequency

Overview

Journal Ann Neurol

Specialty Neurology

Date 2010 May 4

PMID 20437568

Citations 31

Authors

Courtney Lawrence

Brandon Scott Martin

Chengsan Sun

John Williamson

Jaideep Kapur

Affiliations

Soon will be listed here.

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

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Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.

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Limbic progesterone receptor activity enhances neuronal excitability and seizures.

Shiono S, Sun H, Batabyal T, Labuz A, Williamson J, Kapur J Epilepsia. 2021; 62(8):1946-1959.

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