Neonatal Diabetes Mellitus: a Model for Personalized Medicine

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2010 May 4

PMID 20434356

Citations 29

Authors

Siri Atma W Greeley

Susan E Tucker

Rochelle N Naylor

Graeme I Bell

Louis H Philipson

Affiliations

Soon will be listed here.

Abstract

Neonatal diabetes mellitus occurs in approximately 1 out of every 100,000 live births. It can be either permanent or transient, and recent studies indicate that is likely to have an underlying genetic cause, particularly when diagnosed before 6 months of age. Permanent neonatal diabetes is most commonly due to activating mutations in either of the genes encoding the two subunits of the ATP-sensitive potassium channel. In most of these patients, switching from insulin to oral sulfonylurea therapy leads to improved metabolic control, as well as possible amelioration of occasional associated neurodevelopmental disabilities. It remains to be determined what is the most appropriate treatment of other causes. The diagnosis and treatment of neonatal diabetes, therefore, represents a model for personalized medicine.

Citing Articles

Diagnosis and Treatment of Neonatal Diabetes Caused by ATP-Channel Mutations: Genetic Insights, Sulfonylurea Therapy, and Future Directions.

Trada M, Novara C, Moretto M, Burzi E, Tinti D, de Sanctis L Children (Basel). 2025; 12(2).

PMID: 40003320 PMC: 11854417. DOI: 10.3390/children12020219.

What Do We Know about Neonatal Diabetes caused by Mutations?.

de Souza R, Cabello P, Lopes Rosado E, Junior M, Abreu G Curr Diabetes Rev. 2024; 21(1):e290124226471.

PMID: 38299270 DOI: 10.2174/0115733998265866231204070606.

Exploring the Diet-Gut Microbiota-Epigenetics Crosstalk Relevant to Neonatal Diabetes.

Alsharairi N Genes (Basel). 2023; 14(5).

PMID: 37239377 PMC: 10218220. DOI: 10.3390/genes14051017.

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents.

Greeley S, Polak M, Njolstad P, Barbetti F, Williams R, Castano L Pediatr Diabetes. 2022; 23(8):1188-1211.

PMID: 36537518 PMC: 10107883. DOI: 10.1111/pedi.13426.

Genome Editing and Human Pluripotent Stem Cell Technologies for in vitro Monogenic Diabetes Modeling.

Dabi Y, Degechisa S Diabetes Metab Syndr Obes. 2022; 15:1785-1797.

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