Modulation of Host Innate and Adaptive Immune Defenses by Cytomegalovirus: Timing is Everything

Overview

Journal J Intern Med

Specialty General Medicine

Date 2010 May 4

PMID 20433576

Citations 63

Authors

A Loewendorf

C A Benedict

Affiliations

Soon will be listed here.

Abstract

Human cytomegalovirus (HCMV) (HHV-5, a beta-herpesvirus) causes the vast majority of infection-related congenital birth defects, and can trigger severe disease in immune suppressed individuals. The high prevalence of societal infection, the establishment of lifelong persistence and the growing number of immune-related diseases where HCMV is touted as a potential promoter is slowly heightening public awareness to this virus. The millions of years of co-evolution between CMV and the immune system of its host provides for a unique opportunity to study immune defense strategies, and pathogen counterstrategies. Dissecting the timing of the cellular and molecular processes that regulate innate and adaptive immunity to this persistent virus has revealed a complex defense network that is shaped by CMV immune modulation, resulting in a finely tuned host-pathogen relationship.

Citing Articles

Immune surveillance of cytomegalovirus in tissues.

Mihalic A, Zeleznjak J, Lisnic B, Jonjic S, Juranic Lisnic V, Brizic I Cell Mol Immunol. 2024; 21(9):959-981.

PMID: 39134803 PMC: 11364667. DOI: 10.1038/s41423-024-01186-2.

Profiling of Commonly Used Post-transplant Immunosuppressants Reveals Distinct Impact on Antiviral T-cell Immunity Towards CMV.

Krueger M, Bonifacius A, Dragon A, Santamorena M, Nashan B, Taubert R Transpl Int. 2024; 37:12720.

PMID: 38655204 PMC: 11035762. DOI: 10.3389/ti.2024.12720.

Mouse Models for Human Herpesviruses.

Kutle I, Dittrich A, Wirth D Pathogens. 2023; 12(7).

PMID: 37513800 PMC: 10384569. DOI: 10.3390/pathogens12070953.

The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of and Other IRF3-Driven Genes.

Schwanke H, Magalhaes V, Schmelz S, Wyler E, Hennig T, Gunther T J Virol. 2023; 97(6):e0040023.

PMID: 37289084 PMC: 10308904. DOI: 10.1128/jvi.00400-23.

Personalize, participate, predict, and prevent: 4Ps in inflammatory bowel disease.

Lenti M, Scribano M, Biancone L, Ciccocioppo R, Pugliese D, Pastorelli L Front Med (Lausanne). 2023; 10:1031998.

PMID: 37113615 PMC: 10126747. DOI: 10.3389/fmed.2023.1031998.

References

Andoniou C, Coudert J, Degli-Esposti M . Killers and beyond: NK-cell-mediated control of immune responses. Eur J Immunol. 2008; 38(11):2938-42. DOI: 10.1002/eji.200838882. View

Banks T, Rickert S, Benedict C, Ma L, Ko M, Meier J . A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol. 2005; 174(11):7217-25. DOI: 10.4049/jimmunol.174.11.7217. View

Shinkura R, Kitada K, Matsuda F, Tashiro K, Ikuta K, Suzuki M . Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet. 1999; 22(1):74-7. DOI: 10.1038/8780. View

Zucchini N, Bessou G, Traub S, Robbins S, Uematsu S, Akira S . Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J Immunol. 2008; 180(9):5799-803. DOI: 10.4049/jimmunol.180.9.5799. View

Raftery M, Hitzler M, Winau F, Giese T, Plachter B, Kaufmann S . Inhibition of CD1 antigen presentation by human cytomegalovirus. J Virol. 2008; 82(9):4308-19. PMC: 2293051. DOI: 10.1128/JVI.01447-07. View

Mailliard R, Alber S, Shen H, Watkins S, Kirkwood J, Herberman R . IL-18-induced CD83+CCR7+ NK helper cells. J Exp Med. 2005; 202(7):941-53. PMC: 2213172. DOI: 10.1084/jem.20050128. View

Baccala R, Gonzalez-Quintial R, Lawson B, Stern M, Kono D, Beutler B . Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol. 2009; 5(8):448-56. DOI: 10.1038/nrrheum.2009.136. View

Doherty P, Allan J . Anti-asialo GM1 eliminates both inflammatory process and cytotoxic T-cell function in the lymphocytic choriomeningitis adoptive transfer model. Cell Immunol. 1987; 107(1):1-7. DOI: 10.1016/0008-8749(87)90259-0. View

Chang W, Barry P, Szubin R, Wang D, Baumgarth N . Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog. Virology. 2009; 390(2):330-7. PMC: 2747589. DOI: 10.1016/j.virol.2009.05.013. View

10.

Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K . Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 2006; 4(3):203-13. DOI: 10.1093/bfgp/4.3.203. View

11.

Pyzik M, Kielczewska A, Vidal S . NK cell receptors and their MHC class I ligands in host response to cytomegalovirus: insights from the mouse genome. Semin Immunol. 2008; 20(6):331-42. DOI: 10.1016/j.smim.2008.09.003. View

12.

Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T . Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci U S A. 2004; 101(47):16606-11. PMC: 534504. DOI: 10.1073/pnas.0407522101. View

13.

Munks M, Pinto A, Doom C, Hill A . Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection. J Immunol. 2007; 178(11):7235-41. DOI: 10.4049/jimmunol.178.11.7235. View

14.

Varani S, Cederarv M, Feld S, Tammik C, Frascaroli G, Landini M . Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells. J Immunol. 2007; 179(11):7767-76. DOI: 10.4049/jimmunol.179.11.7767. View

15.

Krug A, French A, Barchet W, Fischer J, Dzionek A, Pingel J . TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity. 2004; 21(1):107-19. DOI: 10.1016/j.immuni.2004.06.007. View

16.

Raftery M, Schwab M, Eibert S, Samstag Y, Walczak H, Schonrich G . Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy. Immunity. 2002; 15(6):997-1009. DOI: 10.1016/s1074-7613(01)00239-4. View

17.

Kelly J, Takeda K, Darcy P, Yagita H, Smyth M . A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo. J Immunol. 2002; 168(9):4472-9. DOI: 10.4049/jimmunol.168.9.4472. View

18.

Zucchini N, Bessou G, Robbins S, Chasson L, Raper A, Crocker P . Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection. Int Immunol. 2007; 20(1):45-56. PMC: 7110020. DOI: 10.1093/intimm/dxm119. View

19.

Walzer T, Dalod M, Vivier E, Zitvogel L . Natural killer cell-dendritic cell crosstalk in the initiation of immune responses. Expert Opin Biol Ther. 2005; 5 Suppl 1:S49-59. DOI: 10.1517/14712598.5.1.s49. View

20.

Montag C, Wagner J, Gruska I, Hagemeier C . Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling. J Virol. 2006; 80(23):11686-98. PMC: 1642604. DOI: 10.1128/JVI.01168-06. View