Prevalence of Asymptomatic Carotid Artery Stenosis in the General Population: an Individual Participant Data Meta-analysis

Overview

Journal Stroke

Specialties Cardiology & Vascular Diseases
Neurology

Date 2010 May 1

PMID 20431077

Citations 120

Authors

Marjolein de Weerd

Jacoba P Greving

Bo Hedblad

Matthias W Lorenz

Ellisiv B Mathiesen

Daniel H OLeary

Maria Rosvall

Matthias Sitzer

Erik Buskens

Michiel L Bots

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data.

Methods: We performed an individual participant data meta-analysis (23 706 participants) of 4 population-based studies (Malmö Diet and Cancer Study, Tromsø, Carotid Atherosclerosis Progression Study, and Cardiovascular Health Study). Outcomes of interest were asymptomatic moderate (> or =50%) and severe carotid stenosis (> or =70%).

Results: Prevalence of moderate asymptomatic carotid stenosis ranged from 0.2% (95% CI, 0.0% to 0.4%) in men aged <50 years to 7.5% (5.2% to 10.5%) in men aged > or =80 years. For women, this prevalence increased from 0% (0% to 0.2%) to 5.0% (3.1% to 7.5%). Prevalence of severe asymptomatic carotid stenosis ranged from 0.1% (0.0% to 0.3%) in men aged <50 years to 3.1% (1.7% to 5.3%) in men aged > or =80. For women, this prevalence increased from 0% (0.0% to 0.2%) to 0.9% (0.3% to 2.4%).

Conclusions: The prevalence of severe asymptomatic carotid stenosis in the general population ranges from 0% to 3.1%, which is useful information in the discussion on the cost-effectiveness of screening.

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