Harsh Family Climate in Early Life Presages the Emergence of a Proinflammatory Phenotype in Adolescence

Overview

Journal Psychol Sci

Specialty Psychology

Date 2010 May 1

PMID 20431047

Citations 176

Authors

Gregory E Miller

Edith Chen

Affiliations

Soon will be listed here.

Abstract

A growing body of evidence indicates that children reared in harsh families are prone to chronic diseases and premature death later in life. To shed light on the mechanisms potentially underlying this phenomenon, we evaluated the hypothesis that harsh families engender a proinflammatory phenotype in children that is marked by exaggerated cytokine responses to bacterial stimuli and resistance to the anti-inflammatory properties of cortisol. We repeatedly measured psychological stress and inflammatory activity in 135 female adolescents on four occasions over 1.5 years. To the extent that they were reared in harsh families, participants displayed an increasingly proinflammatory phenotype during the follow-up analyses. This phenotype was marked by increasingly pronounced cytokine responses to in vitro bacterial challenge and a progressive desensitization of the glucocorticoid receptor, which hampered cortisol's ability to properly regulate inflammatory responses. If sustained, these tendencies may place children from harsh families on a developmental trajectory toward the chronic diseases of aging.

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References

Webster J, Tonelli L, Sternberg E . Neuroendocrine regulation of immunity. Annu Rev Immunol. 2002; 20:125-63. DOI: 10.1146/annurev.immunol.20.082401.104914. View

Nathan C . Points of control in inflammation. Nature. 2002; 420(6917):846-52. DOI: 10.1038/nature01320. View

Pollak S . Mechanisms Linking Early Experience and the Emergence of Emotions: Illustrations From the Study of Maltreated Children. Curr Dir Psychol Sci. 2011; 17(6):370-375. PMC: 3119575. DOI: 10.1111/j.1467-8721.2008.00608.x. View

Miller G, Chen E . Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence. Psychosom Med. 2007; 69(5):402-9. DOI: 10.1097/PSY.0b013e318068fcf9. View

Miller G, Chen E . Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma. Proc Natl Acad Sci U S A. 2006; 103(14):5496-501. PMC: 1414639. DOI: 10.1073/pnas.0506312103. View

Dong M, Giles W, Felitti V, Dube S, Williams J, Chapman D . Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation. 2004; 110(13):1761-6. DOI: 10.1161/01.CIR.0000143074.54995.7F. View

Luecken L, Lemery K . Early caregiving and physiological stress responses. Clin Psychol Rev. 2004; 24(2):171-91. DOI: 10.1016/j.cpr.2004.01.003. View

Dube S, Fairweather D, Pearson W, Felitti V, Anda R, Croft J . Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med. 2009; 71(2):243-50. PMC: 3318917. DOI: 10.1097/PSY.0b013e3181907888. View

Taylor S, Lehman B, Kiefe C, Seeman T . Relationship of early life stress and psychological functioning to adult C-reactive protein in the coronary artery risk development in young adults study. Biol Psychiatry. 2006; 60(8):819-24. DOI: 10.1016/j.biopsych.2006.03.016. View

10.

Adrian C, Hammen C . Stress exposure and stress generation in children of depressed mothers. J Consult Clin Psychol. 1993; 61(2):354-9. DOI: 10.1037//0022-006x.61.2.354. View

11.

McEwen B . Protective and damaging effects of stress mediators. N Engl J Med. 1998; 338(3):171-9. DOI: 10.1056/NEJM199801153380307. View

12.

Taylor S, Eisenberger N, Saxbe D, Lehman B, Lieberman M . Neural responses to emotional stimuli are associated with childhood family stress. Biol Psychiatry. 2006; 60(3):296-301. DOI: 10.1016/j.biopsych.2005.09.027. View

13.

Zhang T, Bagot R, Parent C, Nesbitt C, Bredy T, Caldji C . Maternal programming of defensive responses through sustained effects on gene expression. Biol Psychol. 2006; 73(1):72-89. DOI: 10.1016/j.biopsycho.2006.01.009. View

14.

Repetti R, Taylor S, Seeman T . Risky families: family social environments and the mental and physical health of offspring. Psychol Bull. 2002; 128(2):330-66. View

15.

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

16.

Paffenbarger Jr R, Blair S, Lee I, HYDE R . Measurement of physical activity to assess health effects in free-living populations. Med Sci Sports Exerc. 1993; 25(1):60-70. DOI: 10.1249/00005768-199301000-00010. View

17.

Pace T, Mletzko T, Alagbe O, Musselman D, Nemeroff C, Miller A . Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry. 2006; 163(9):1630-3. DOI: 10.1176/ajp.2006.163.9.1630. View

18.

Buysse D, Reynolds 3rd C, Monk T, BERMAN S, Kupfer D . The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989; 28(2):193-213. DOI: 10.1016/0165-1781(89)90047-4. View

19.

Dahl R . Adolescent brain development: a period of vulnerabilities and opportunities. Keynote address. Ann N Y Acad Sci. 2004; 1021:1-22. DOI: 10.1196/annals.1308.001. View

20.

Chen E, Langer D, Raphaelson Y, Matthews K . Socioeconomic status and health in adolescents: the role of stress interpretations. Child Dev. 2004; 75(4):1039-52. DOI: 10.1111/j.1467-8624.2004.00724.x. View