Compartmentalized Organization: a Common and Required Feature of Stem Cell Niches?

Overview

Journal Development

Specialty Biology

Date 2010 May 1

PMID 20430743

Citations 37

Authors

Valentina Greco

Shangqin Guo

Affiliations

Soon will be listed here.

Abstract

A key question in the stem cell field is how to balance the slow cycling of stem cells with active organ growth. Recent studies of the hair follicle stem cell niche have shown that this can be achieved by organizing the stem cell niche into two compartments: one that engages in immediate, rapid new growth and one that contributes later to long-term growth that fuels hair regeneration. Based on these and other recent findings, we propose that several other adult stem cell niches, including those in the blood, intestine and brain, have a similar bi-compartmental organization and that stem cells might work cooperatively with their progeny to sustain tissue regeneration.

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References

Spangrude G, Heimfeld S, Weissman I . Purification and characterization of mouse hematopoietic stem cells. Science. 1988; 241(4861):58-62. DOI: 10.1126/science.2898810. View

Wulczyn F, Smirnova L, Rybak A, Brandt C, Kwidzinski E, Ninnemann O . Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 2006; 21(2):415-26. DOI: 10.1096/fj.06-6130com. View

Barroca V, Lassalle B, Coureuil M, Louis J, Le Page F, Testart J . Mouse differentiating spermatogonia can generate germinal stem cells in vivo. Nat Cell Biol. 2008; 11(2):190-6. DOI: 10.1038/ncb1826. View

Lo Celso C, Fleming H, Wu J, Zhao C, Miake-Lye S, Fujisaki J . Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature. 2008; 457(7225):92-6. PMC: 2820276. DOI: 10.1038/nature07434. View

Lakso M, Sauer B, Mosinger Jr B, Lee E, Manning R, Yu S . Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A. 1992; 89(14):6232-6. PMC: 49474. DOI: 10.1073/pnas.89.14.6232. View

Zhang Y, Cheong J, Ciapurin N, McDermitt D, Tumbar T . Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell. 2009; 5(3):267-78. PMC: 2756832. DOI: 10.1016/j.stem.2009.06.004. View

Mannik J, Alzayady K, Ghazizadeh S . Regeneration of multilineage skin epithelia by differentiated keratinocytes. J Invest Dermatol. 2009; 130(2):388-97. PMC: 2879264. DOI: 10.1038/jid.2009.244. View

Lu J, Guo S, Ebert B, Zhang H, Peng X, Bosco J . MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008; 14(6):843-53. PMC: 2688789. DOI: 10.1016/j.devcel.2008.03.012. View

Pastrana E, Cheng L, Doetsch F . Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proc Natl Acad Sci U S A. 2009; 106(15):6387-92. PMC: 2669396. DOI: 10.1073/pnas.0810407106. View

10.

Plikus M, Mayer J, de la Cruz D, Baker R, Maini P, Maxson R . Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008; 451(7176):340-4. PMC: 2696201. DOI: 10.1038/nature06457. View

11.

Sato T, Vries R, Snippert H, van de Wetering M, Barker N, Stange D . Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009; 459(7244):262-5. DOI: 10.1038/nature07935. View

12.

Bowie M, McKnight K, Kent D, McCaffrey L, Hoodless P, Eaves C . Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest. 2006; 116(10):2808-16. PMC: 1578623. DOI: 10.1172/JCI28310. View

13.

Muller-Rover S, Handjiski B, van der Veen C, Eichmuller S, Foitzik K, McKay I . A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001; 117(1):3-15. DOI: 10.1046/j.0022-202x.2001.01377.x. View

14.

Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T . Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009; 15(6):696-700. DOI: 10.1038/nm.1973. View

15.

Foudi A, Hochedlinger K, Van Buren D, Schindler J, Jaenisch R, Carey V . Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol. 2008; 27(1):84-90. PMC: 2805441. DOI: 10.1038/nbt.1517. View

16.

Wilson A, Laurenti E, Oser G, van der Wath R, Blanco-Bose W, Jaworski M . Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008; 135(6):1118-29. DOI: 10.1016/j.cell.2008.10.048. View

17.

Essers M, Offner S, Blanco-Bose W, Waibler Z, Kalinke U, Duchosal M . IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 2009; 458(7240):904-8. DOI: 10.1038/nature07815. View

18.

Jaks V, Barker N, Kasper M, van Es J, Snippert H, Clevers H . Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 2008; 40(11):1291-9. DOI: 10.1038/ng.239. View

19.

Glauche I, Moore K, Thielecke L, Horn K, Loeffler M, Roeder I . Stem cell proliferation and quiescence--two sides of the same coin. PLoS Comput Biol. 2009; 5(7):e1000447. PMC: 2704962. DOI: 10.1371/journal.pcbi.1000447. View

20.

Wilson A, Oser G, Jaworski M, Blanco-Bose W, Laurenti E, Adolphe C . Dormant and self-renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci. 2007; 1106:64-75. DOI: 10.1196/annals.1392.021. View