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Imaging Macrophages in Trehalose with SIMS

Overview
Journal Appl Surf Sci
Date 2010 Apr 30
PMID 20428458
Citations 4
Authors
S A Parry
M E Kurczy
X Fan
M S Halleck
R A Schlegel
N Winograd
Affiliations
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Abstract

Phagocytosis is a major component of the animal immune system where apoptotic cellular material, metabolites, and waste are safely processed. Further, efficient phagocytosis by macrophages is key to maintaining healthy vascular systems and preventing atherosclerosis. Single-cell images of macrophage phagocytosis of red blood cells, RBCs, and polystyrene microspheres have been chemically mapped with TOF-SIMS. We demonstrate here cholesterol and phosphocholine localizations as relative to time and activity.

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