Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2010 Apr 29

PMID 20425514

Citations 27

Authors

S Hasan Arshad

Affiliations

Soon will be listed here.

Abstract

Common indoor allergens include house dust mite, cockroach, animal dander, and certain molds. In genetically susceptible children, exposure to these indoor allergens during the critical postnatal period may lead to sensitization in early childhood. Consistent evidence indicates that children sensitized to common indoor allergens are at several-fold higher risk of asthma and allergy. Due to conflicting evidence from prospective studies, some doubt remains regarding a direct and dose-response relationship between exposure and development of asthma. However, in recent years, evidence has accumulated that exposure to indoor allergen causes asthma and allergy, but this effect may depend on dose and type of allergen as well as the underlying genetic susceptibility of the child.

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References

Gent J, Belanger K, Triche E, Bracken M, Beckett W, Leaderer B . Association of pediatric asthma severity with exposure to common household dust allergens. Environ Res. 2009; 109(6):768-74. PMC: 2706291. DOI: 10.1016/j.envres.2009.04.010. View

Caudri D, Wijga A, Scholtens S, Kerkhof M, Gerritsen J, Ruskamp J . Early daycare is associated with an increase in airway symptoms in early childhood but is no protection against asthma or atopy at 8 years. Am J Respir Crit Care Med. 2009; 180(6):491-8. DOI: 10.1164/rccm.200903-0327OC. View

Huss K, Adkinson Jr N, Eggleston P, Dawson C, Van Natta M, Hamilton R . House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program. J Allergy Clin Immunol. 2001; 107(1):48-54. DOI: 10.1067/mai.2001.111146. View

Hunninghake G, Soto-Quiros M, Lasky-Su J, Avila L, Ly N, Liang C . Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol. 2008; 122(1):93-8, 98.e1-5. PMC: 6124308. DOI: 10.1016/j.jaci.2008.03.015. View

Bisgaard H, Simpson A, Palmer C, Bonnelykke K, McLean I, Mukhopadhyay S . Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med. 2008; 5(6):e131. PMC: 2504043. DOI: 10.1371/journal.pmed.0050131. View

Peat J, Tovey E, Mellis C, Leeder S, Woolcock A . Importance of house dust mite and Alternaria allergens in childhood asthma: an epidemiological study in two climatic regions of Australia. Clin Exp Allergy. 1993; 23(10):812-20. DOI: 10.1111/j.1365-2222.1993.tb00258.x. View

Saglani S, Mathie S, Gregory L, Bell M, Bush A, Lloyd C . Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am J Respir Cell Mol Biol. 2009; 41(3):281-9. PMC: 3380517. DOI: 10.1165/rcmb.2008-0396OC. View

Simons E, Curtin-Brosnan J, Buckley T, Breysse P, Eggleston P . Indoor environmental differences between inner city and suburban homes of children with asthma. J Urban Health. 2007; 84(4):577-90. PMC: 2219555. DOI: 10.1007/s11524-007-9205-3. View

Tariq S, Matthews S, Hakim E, Stevens M, Arshad S, Hide D . The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. J Allergy Clin Immunol. 1998; 101(5):587-93. DOI: 10.1016/S0091-6749(98)70164-2. View

10.

Peters J, Suglia S, Platts-Mills T, Hosen J, Gold D, Wright R . Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS. J Allergy Clin Immunol. 2009; 123(5):1041-6. PMC: 2777675. DOI: 10.1016/j.jaci.2009.02.027. View

11.

Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U . Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet. 2006; 368(9537):763-70. DOI: 10.1016/S0140-6736(06)69286-6. View

12.

Dharmage S, Bailey M, Raven J, Mitakakis T, Cheng A, Guest D . Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure. Am J Respir Crit Care Med. 2001; 164(1):65-71. DOI: 10.1164/ajrccm.164.1.9911066. View

13.

Gereda J, Leung D, Thatayatikom A, Streib J, Price M, Klinnert M . Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet. 2000; 355(9216):1680-3. DOI: 10.1016/s0140-6736(00)02239-x. View

14.

Raherison C, Penard-Morand C, Moreau D, Caillaud D, Charpin D, Kopferschmitt C . Smoking exposure and allergic sensitization in children according to maternal allergies. Ann Allergy Asthma Immunol. 2008; 100(4):351-7. DOI: 10.1016/S1081-1206(10)60598-4. View

15.

Nowak D, Heinrich J, Jorres R, Wassmer G, Berger J, Beck E . Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J. 1996; 9(12):2541-52. DOI: 10.1183/09031936.96.09122541. View

16.

Litonjua A, Carey V, Burge H, Weiss S, Gold D . Exposure to cockroach allergen in the home is associated with incident doctor-diagnosed asthma and recurrent wheezing. J Allergy Clin Immunol. 2001; 107(1):41-7. DOI: 10.1067/mai.2001.111143. View

17.

Huang J, Chen C, Kuo M, Hsieh K . Exposure to a high concentration of mite allergen in early infancy is a risk factor for developing atopic dermatitis: a 3-year follow-up study. Pediatr Allergy Immunol. 2001; 12(1):11-6. DOI: 10.1034/j.1399-3038.2001.012001011.x. View

18.

Oddera S, Silvestri M, Penna R, Galeazzi G, Crimi E, Rossi G . Airway eosinophilic inflammation and bronchial hyperresponsiveness after allergen inhalation challenge in asthma. Lung. 1998; 176(4):237-47. DOI: 10.1007/pl00007606. View

19.

Salo P, Arbes Jr S, Crockett P, Thorne P, Cohn R, Zeldin D . Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol. 2008; 121(3):678-684.e2. PMC: 2376121. DOI: 10.1016/j.jaci.2007.12.1164. View

20.

Gehring U, Heinrich J, Jacob B, Richter K, Fahlbusch B, Schlenvoigt G . Respiratory symptoms in relation to indoor exposure to mite and cat allergens and endotoxins. Indoor Factors and Genetics in Asthma (INGA) Study Group. Eur Respir J. 2001; 18(3):555-63. DOI: 10.1183/09031936.01.00096801. View