Tissue Engineering Strategies for the Regeneration of Orthopedic Interfaces

Overview

Journal Ann Biomed Eng

Specialty Biomedical Engineering

Date 2010 Apr 28

PMID 20422291

Citations 56

Authors

Helen H Lu

Siddarth D Subramony

Margaret K Boushell

Xinzhi Zhang

Affiliations

Soon will be listed here.

Abstract

A major focus in the field of orthopedic tissue engineering is the development of tissue engineered bone and soft tissue grafts with biomimetic functionality to allow for their translation to the clinical setting. One of the most significant challenges of this endeavor is promoting the biological fixation of these grafts with each other as well as the implant site. Such fixation requires strategic biomimicry to be incorporated into the scaffold design in order to re-establish the critical structure-function relationship of the native soft tissue-to-bone interface. The integration of distinct tissue types (e.g. bone and soft tissues such as cartilage, ligaments, or tendons), necessitates a multi-phased or stratified scaffold with distinct yet continuous tissue regions accompanied by a gradient of mechanical properties. This review discusses tissue engineering strategies for regenerating common tissue-to-tissue interfaces (ligament-to-bone, tendon-to-bone, or cartilage-to-bone), and the strategic biomimicry implemented in stratified scaffold design for multi-tissue regeneration. Potential challenges and future directions in this emerging field will also be presented. It is anticipated that interface tissue engineering will enable integrative soft tissue repair, and will be instrumental for the development of complex musculoskeletal tissue systems with biomimetic complexity and functionality.

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References

Lu H, Cooper Jr J, Manuel S, Freeman J, Attawia M, Ko F . Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies. Biomaterials. 2005; 26(23):4805-16. DOI: 10.1016/j.biomaterials.2004.11.050. View

Huangfu X, Zhao J . Tendon-bone healing enhancement using injectable tricalcium phosphate in a dog anterior cruciate ligament reconstruction model. Arthroscopy. 2007; 23(5):455-62. DOI: 10.1016/j.arthro.2006.12.031. View

Li X, Xie J, Lipner J, Yuan X, Thomopoulos S, Xia Y . Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett. 2009; 9(7):2763-8. PMC: 2726708. DOI: 10.1021/nl901582f. View

Larkin L, Calve S, Kostrominova T, Arruda E . Structure and functional evaluation of tendon-skeletal muscle constructs engineered in vitro. Tissue Eng. 2007; 12(11):3149-58. PMC: 2798802. DOI: 10.1089/ten.2006.12.3149. View

Niederauer G, Slivka M, Leatherbury N, Korvick D, Harroff H, Ehler W . Evaluation of multiphase implants for repair of focal osteochondral defects in goats. Biomaterials. 2000; 21(24):2561-74. DOI: 10.1016/s0142-9612(00)00124-1. View

Swieszkowski W, Tuan B, Kurzydlowski K, Hutmacher D . Repair and regeneration of osteochondral defects in the articular joints. Biomol Eng. 2007; 24(5):489-95. DOI: 10.1016/j.bioeng.2007.07.014. View

Nawata K, Minamizaki T, Yamashita Y, Teshima R . Development of the attachment zones in the rat anterior cruciate ligament: changes in the distributions of proliferating cells and fibrillar collagens during postnatal growth. J Orthop Res. 2002; 20(6):1339-44. DOI: 10.1016/S0736-0266(02)00048-7. View

Fujioka H, Thakur R, Wang G, Mizuno K, Balian G, Hurwitz S . Comparison of surgically attached and non-attached repair of the rat Achilles tendon-bone interface. Cellular organization and type X collagen expression. Connect Tissue Res. 1998; 37(3-4):205-18. DOI: 10.3109/03008209809002440. View

Spalazzi J, Dagher E, Doty S, Guo X, Rodeo S, Lu H . In vivo evaluation of a tri-phasic composite scaffold for anterior cruciate ligament-to-bone integration. Conf Proc IEEE Eng Med Biol Soc. 2007; 2006:525-8. DOI: 10.1109/IEMBS.2006.259296. View

10.

Youn I, Jones D, Andrews P, Cook M, Suh J . Periosteal augmentation of a tendon graft improves tendon healing in the bone tunnel. Clin Orthop Relat Res. 2004; (419):223-31. DOI: 10.1097/00003086-200402000-00037. View

11.

Itoi E, Berglund L, Grabowski J, Schultz F, Growney E, Morrey B . Tensile properties of the supraspinatus tendon. J Orthop Res. 1995; 13(4):578-84. DOI: 10.1002/jor.1100130413. View

12.

Derwin K, Baker A, Spragg R, Leigh D, Iannotti J . Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties. J Bone Joint Surg Am. 2006; 88(12):2665-72. DOI: 10.2106/JBJS.E.01307. View

13.

COOPER R, Misol S . Tendon and ligament insertion. A light and electron microscopic study. J Bone Joint Surg Am. 1970; 52(1):1-20. View

14.

Altman G, Horan R, Weitzel P, Richmond J . The use of long-term bioresorbable scaffolds for anterior cruciate ligament repair. J Am Acad Orthop Surg. 2008; 16(4):177-87. DOI: 10.5435/00124635-200804000-00001. View

15.

Erisken C, Kalyon D, Wang H . Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications. Biomaterials. 2008; 29(30):4065-73. DOI: 10.1016/j.biomaterials.2008.06.022. View

16.

Paxton J, Donnelly K, Keatch R, Baar K . Engineering the bone-ligament interface using polyethylene glycol diacrylate incorporated with hydroxyapatite. Tissue Eng Part A. 2008; 15(6):1201-9. DOI: 10.1089/ten.tea.2008.0105. View

17.

Moffat K, Kwei A, Spalazzi J, Doty S, Levine W, Lu H . Novel nanofiber-based scaffold for rotator cuff repair and augmentation. Tissue Eng Part A. 2008; 15(1):115-26. PMC: 2809655. DOI: 10.1089/ten.tea.2008.0014. View

18.

Harley B, Lynn A, Wissner-Gross Z, Bonfield W, V Yannas I, Gibson L . Design of a multiphase osteochondral scaffold III: Fabrication of layered scaffolds with continuous interfaces. J Biomed Mater Res A. 2009; 92(3):1078-93. DOI: 10.1002/jbm.a.32387. View

19.

Lyons T, Stoddart R, McClure S, McClure J . The tidemark of the chondro-osseous junction of the normal human knee joint. J Mol Histol. 2005; 36(3):207-15. DOI: 10.1007/s10735-005-3283-x. View

20.

Spalazzi J, Doty S, Moffat K, Levine W, Lu H . Development of controlled matrix heterogeneity on a triphasic scaffold for orthopedic interface tissue engineering. Tissue Eng. 2007; 12(12):3497-508. DOI: 10.1089/ten.2006.12.3497. View