Ion Channels at the Nucleus: Electrophysiology Meets the Genome

Overview

Journal Mol Plant

Publisher Cell Press

Specialties Biology
Molecular Biology

Date 2010 Apr 23

PMID 20410254

Citations 24

Authors

Antonius J M Matzke

Thomas M Weiger

Marjori Matzke

Affiliations

Soon will be listed here.

Abstract

The nuclear envelope is increasingly viewed from an electrophysiological perspective by researchers interested in signal transduction pathways that influence gene transcription and other processes in the nucleus. Here, we describe evidence for ion channels and transporters in the nuclear membranes and for possible ion gating by the nuclear pores. We argue that a systems-level understanding of cellular regulation is likely to require the assimilation of nuclear electrophysiology into molecular and biochemical signaling pathways.

Citing Articles

L-type Voltage-Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc.

Poillot P, Snuggs J, Le Maitre C, Huyghe J JOR Spine. 2023; 5(4):e1213.

PMID: 36601377 PMC: 9799080. DOI: 10.1002/jsp2.1213.

Grease in the Nucleus: Insights into the Dynamic Life of Nuclear Membranes.

Anand D, Chaudhuri A J Membr Biol. 2022; 256(2):137-145.

PMID: 36331589 PMC: 10082704. DOI: 10.1007/s00232-022-00272-8.

The Nuclear Envelope as a Regulator of Immune Cell Function.

Selezneva A, Gibb A, Willis D Front Immunol. 2022; 13:840069.

PMID: 35757775 PMC: 9226455. DOI: 10.3389/fimmu.2022.840069.

Evaluation of chromatin mesoscale organization.

Lorber D, Volk T APL Bioeng. 2022; 6(1):010902.

PMID: 35071965 PMC: 8758204. DOI: 10.1063/5.0069286.

The Distribution and Role of the CFTR Protein in the Intracellular Compartments.

Lukasiak A, Zajac M Membranes (Basel). 2021; 11(11).

PMID: 34832033 PMC: 8618639. DOI: 10.3390/membranes11110804.

References

Terry L, Wente S . Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport. Eukaryot Cell. 2009; 8(12):1814-27. PMC: 2794212. DOI: 10.1128/EC.00225-09. View

Wang H, Clapham D . Conformational changes of the in situ nuclear pore complex. Biophys J. 1999; 77(1):241-7. PMC: 1300325. DOI: 10.1016/S0006-3495(99)76885-2. View

Vadassery J, Oelmuller R . Calcium signaling in pathogenic and beneficial plant microbe interactions: what can we learn from the interaction between Piriformospora indica and Arabidopsis thaliana. Plant Signal Behav. 2009; 4(11):1024-7. PMC: 2819509. DOI: 10.4161/psb.4.11.9800. View

Nagai T, Yamada S, Tominaga T, Ichikawa M, Miyawaki A . Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A. 2004; 101(29):10554-9. PMC: 490022. DOI: 10.1073/pnas.0400417101. View

Sakai R, Repunte-Canonigo V, Raj C, Knopfel T . Design and characterization of a DNA-encoded, voltage-sensitive fluorescent protein. Eur J Neurosci. 2001; 13(12):2314-8. DOI: 10.1046/j.0953-816x.2001.01617.x. View

Lusk C, Blobel G, King M . Highway to the inner nuclear membrane: rules for the road. Nat Rev Mol Cell Biol. 2007; 8(5):414-20. DOI: 10.1038/nrm2165. View

Merino E, Boal A, Barton J . Biological contexts for DNA charge transport chemistry. Curr Opin Chem Biol. 2008; 12(2):229-37. PMC: 3227530. DOI: 10.1016/j.cbpa.2008.01.046. View

Kramer A, Ludwig Y, Shahin V, Oberleithner H . A pathway separate from the central channel through the nuclear pore complex for inorganic ions and small macromolecules. J Biol Chem. 2007; 282(43):31437-43. DOI: 10.1074/jbc.M703720200. View

Walter A, Mazars C, Maitrejean M, Hopke J, Ranjeva R, Boland W . Structural requirements of jasmonates and synthetic analogues as inducers of Ca2+ signals in the nucleus and the cytosol of plant cells. Angew Chem Int Ed Engl. 2007; 46(25):4783-5. DOI: 10.1002/anie.200604989. View

10.

Crespi M, Frugier F . De novo organ formation from differentiated cells: root nodule organogenesis. Sci Signal. 2008; 1(49):re11. DOI: 10.1126/scisignal.149re11. View

11.

Rodrigues M, Gomes D, Nathanson M, Leite M . Nuclear calcium signaling: a cell within a cell. Braz J Med Biol Res. 2008; 42(1):17-20. PMC: 2989390. DOI: 10.1590/s0100-879x2008005000050. View

12.

Matzke A, Behensky C, Weiger T, Matzke M . A large conductance ion channel in the nuclear envelope of a higher plant cell. FEBS Lett. 1992; 302(1):81-5. DOI: 10.1016/0014-5793(92)80290-w. View

13.

Loewenstein W, Kanno Y, Ito S . Permeability of nuclear membranes. Ann N Y Acad Sci. 1966; 137(2):708-16. DOI: 10.1111/j.1749-6632.1966.tb50192.x. View

14.

Zuleger N, Korfali N, Schirmer E . Inner nuclear membrane protein transport is mediated by multiple mechanisms. Biochem Soc Trans. 2008; 36(Pt 6):1373-7. DOI: 10.1042/BST0361373. View

15.

Wheeler G, Brownlee C . Ca2+ signalling in plants and green algae--changing channels. Trends Plant Sci. 2008; 13(9):506-14. DOI: 10.1016/j.tplants.2008.06.004. View

16.

Gerasimenko O, Gerasimenko J . New aspects of nuclear calcium signalling. J Cell Sci. 2004; 117(Pt 15):3087-94. DOI: 10.1242/jcs.01295. View

17.

Matzke M, Weiger T, Papp I, Matzke A . Nuclear membrane ion channels mediate root nodule development. Trends Plant Sci. 2009; 14(6):295-8. DOI: 10.1016/j.tplants.2009.03.009. View

18.

Krinke O, Novotna Z, Valentova O, Martinec J . Inositol trisphosphate receptor in higher plants: is it real?. J Exp Bot. 2006; 58(3):361-76. DOI: 10.1093/jxb/erl220. View

19.

Meier I, Brkljacic J . Adding pieces to the puzzling plant nuclear envelope. Curr Opin Plant Biol. 2009; 12(6):752-9. DOI: 10.1016/j.pbi.2009.09.016. View

20.

Pante N, Kann M . Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm. Mol Biol Cell. 2002; 13(2):425-34. PMC: 65638. DOI: 10.1091/mbc.01-06-0308. View