Early Morning Hypertension: What Does It Contribute to Overall Cardiovascular Risk Assessment?

The early morning surge in blood pressure (BP) in patients with hypertension is associated with an increased risk of cardiovascular events, such as myocardial infarction and stroke, especially in the presence of comorbidities of diabetes, cardiac and renal disease. A variety of nonhemodynamic factors contribute to the early morning prothrombotic state, including increased atherothrombotic plaque vulnerability and endovascular shear stress, increased coagulability, platelet aggregation, and blood viscosity, and reduced fibrinolysis. In addition, there is a strong association between morning hypertension and vascular damage throughout the circulation, which may involve the myocardium, large arteries, and other target organs. Because morning hypertension is often unrecognized, the resultant target-organ damage may progress relentlessly. With recent advances in ambulatory BP monitoring and BP self-measurement and the inclusion of antihypertensive agents that target the underlying pathophysiological mechanisms related to the morning BP surge (ie, the sympathetic nervous system and the renin-angiotensin-aldosterone system), control of morning hypertension is clinically feasible and should be an important therapeutic target.