Portal Hypertensive Gastropathy: Correlation with Portal Hypertension and Prognosis in Cirrhosis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2010 Apr 22

PMID 20407828

Citations 24

Authors

Moon Young Kim

Hoon Choi

Soon Koo Baik

Chang Jin Yea

Chan Sik Won

Jong Won Byun

So Yeon Park

Yong Hwan Kwon

Jae Woo Kim

Hyun Soo Kim

Sang Ok Kwon

Young Ju Kim

Seung Hwan Cha

Sei Jin Chang

Affiliations

Soon will be listed here.

Abstract

Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis.

Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated.

Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030).

Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

Citing Articles

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Prediction of Esophageal Varices in Viral Hepatitis C Cirrhosis: Performance of Combined Ultrasonography and Clinical Predictors.

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A Nomogram for Predicting Portal Hypertensive Gastropathy in Patients With Liver Cirrhosis: A Retrospective Analysis.

Wang W, Mu Z, Zhu G, Wang T, Lai S, Guo Y Front Med (Lausanne). 2022; 9:834159.

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Portal Hypertensive Gastropathy in Liver Cirrhosis: Prevalence, Natural History, and Risk Factors.

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Application of ultrasound for the diagnosis of cirrhosis/portal hypertension.

Han S, Kim M, Kang S, Baik S J Med Ultrason (2001). 2022; 49(3):321-331.

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