Chromosomal Abnormalities Associated with Mental Retardation in Female Subjects
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Abstract
Chromosomal abnormalities are thought to be the most common cause of mental retardation (MR). However, apart from a few selected types with typical aneuploidy, like Downs syndrome, Klinefelter syndrome, Turner syndrome, etc., the frequency of detectable chromosomal abnormalities in association with idiopathic MR is very low. In this study, we have investigated chromosomal abnormalities in female MR subjects (n = 150) by high-resolution GTG banding. Of them, 30 cases were diagnosed as Downs syndrome. Among the remaining (n = 120), chromosomal abnormalities/marked polymorphisms were detectable in only three MR cases (0.025).
References
1.
Drews C, Yeargin-Allsopp M, Murphy C, DECOUFLE P
. Hearing impairment among 10-year-old children: metropolitan Atlanta, 1985 through 1987. Am J Public Health. 1994; 84(7):1164-6.
PMC: 1614736.
DOI: 10.2105/ajph.84.7.1164.
View
2.
Slavotinek A, Rosenberg M, Knight S, Gaunt L, Fergusson W, Killoran C
. Screening for submicroscopic chromosome rearrangements in children with idiopathic mental retardation using microsatellite markers for the chromosome telomeres. J Med Genet. 1999; 36(5):405-11.
PMC: 1734367.
View
3.
RICHARDSON S, Katz M, Koller H
. Sex differences in number of children administratively classified as mildly mentally retarded: an epidemiological review. Am J Ment Defic. 1986; 91(3):250-6.
View
4.
Velagaleti G, Robinson S, Rouse B, Tonk V, Lockhart L
. Subtelomeric rearrangements in idiopathic mental retardation. Indian J Pediatr. 2005; 72(8):679-85.
DOI: 10.1007/BF02724077.
View
5.
Flint J, Wilkie A
. The genetics of mental retardation. Br Med Bull. 1996; 52(3):453-64.
DOI: 10.1093/oxfordjournals.bmb.a011559.
View