Ricin Toxin Hits a Retrograde Roadblock

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2010 Apr 21

PMID 20403318

Citations 5

Authors

Matthew N J Seaman

Andrew A Peden

Affiliations

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Abstract

To inhibit protein synthesis and induce cell death, plant ricin toxin and bacterial Shiga toxins enter the cell through the endocytic and retrograde secretory pathways. Stechmann et al. (2010) now identify two small-molecule inhibitors that selectively block endosome-to-Golgi retrieval of ricin and Shiga toxins and protect mice from ricin's deadly effects.

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