Common Genetic Variants on Chromosome 9p21 Are Associated with Myocardial Infarction and Type 2 Diabetes in an Italian Population

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2010 Apr 21

PMID 20403154

Citations 13

Authors

Francesca Gori

Claudia Specchia

Silvia Pietri

Luisa Crociati

Simona Barlera

Monica Franciosi

Antonio Nicolucci

Stefano Signorini

Paolo Brambilla

Maria Grazia Franzosi

Affiliations

Soon will be listed here.

Abstract

Background: A genomic region on chromosome 9p21 has been identified as closely associated with increased susceptibility to coronary artery disease (CAD) and to type 2 diabetes (T2D) although the evidence suggests that the genetic variants within chromosome 9p21 that contribute to CAD are different from those that contribute to T2D.We carried out an association case-control study in an Italian population to test the association between two single nucleotide polymorphisms (SNPs) on the 9p21 locus, rs2891168 and rs10811661, previously reported by the PROCARDIS study, and respectively myocardial infarction (MI) and T2D. Our aim was to confirm the previous findings on a larger sample and to verify the independence of their susceptibility effects: rs2891168 associated with MI but not with T2D and rs10811661 associated with T2D but not with MI.

Methods: Genomic DNA samples of 2407 Italians with T2D (602 patients), who had had a recent MI (600), or had both diseases (600) and healthy controls (605) were genotyped for the two SNPs. The genotypes were determined by allelic discrimination using a fluorescent-based TaqMan assay.

Results: SNP rs2891168 was associated with MI, but not with T2D and the G-allele odds ratio (OR) was 1.20 (95% CI 1.02-1.41); SNP rs10811661 was associated with T2D, but not with MI, and the T-allele OR was 1.27 (95% CI 1.04-1.55). ORs estimates from the present study and the PROCARDIS study were pooled and confirmed the previous findings, with greater precision.

Conclusions: Our replication study showed that rs2891168 and rs10811661 are independently associated respectively with MI and T2D in an Italian population. Pooling our results with those reported by the PROCARDIS group, we also obtained a significant result of association with diabetes for rs10811661 in the European population.

Citing Articles

Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to Insulin Resistance and Obesity in Hypercholesterolemic Mice.

Kettunen S, Suoranta T, Beikverdi S, Heikkila M, Slita A, Raty I Cells. 2024; 13(11.

PMID: 38891115 PMC: 11171903. DOI: 10.3390/cells13110983.

CDKN2B-AS (rs2891168), SOD2 (rs4880), and PON1 (rs662) polymorphisms and susceptibility to coronary artery disease and type 2 diabetes mellitus in Iranian patients: A case-control study.

Yari A, Karam Z, Meybodi S, Sargazi M, Saeidi K Health Sci Rep. 2023; 6(11):e1717.

PMID: 38028681 PMC: 10665643. DOI: 10.1002/hsr2.1717.

A Study of Associations Between rs9349379 (PHACTR1), rs2891168 (CDKN2B-AS), rs11838776 (COL4A2) and rs4880 (SOD2) Polymorphic Variants and Coronary Artery Disease in Iranian Population.

Yari A, Saleh-Gohari N, Mirzaee M, Hashemi F, Saeidi K Biochem Genet. 2021; 60(1):106-126.

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Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease.

Goodarzi M, Rotter J Circ Res. 2020; 126(11):1526-1548.

PMID: 32437307 PMC: 7250006. DOI: 10.1161/CIRCRESAHA.119.316065.

Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population.

Kalpana B, Murthy D, Balakrishna N, Aiyengar M Indian Heart J. 2019; 71(3):263-271.

PMID: 31543200 PMC: 6796635. DOI: 10.1016/j.ihj.2019.04.005.

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