Ionic Cross-linked Chitosan Beads for Extended Release of Ciprofloxacin: In Vitro Characterization

Overview

Journal Indian J Pharm Sci

Specialty Pharmacy

Date 2010 Apr 15

PMID 20390075

Citations 4

Authors

A Srinatha

J K Pandit

S Singh

Affiliations

Soon will be listed here.

Abstract

Chitosan beads loaded with ciprofloxacin hydrochloride were fabricated by ionic cross-linking with sodium tripolyphosphate. The beads showed an excellent water retention property. The degradation of fabricated beads was influenced by the pH of test medium. High drug load was achieved within the bead with a short curing time. Drug release was high in acidic medium (pH 1.2) vis-à-vis intestinal medium (pH 7.4). Ciprofloxacin hydrochloride release increased with an increasing concentration of ciprofloxacin and decreasing proportion of chitosan. Drug release followed both first-order and Higuchi's root time kinetics showing non-Fickian release mechanism.

Citing Articles

The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles.

Szymanska E, Wos-Latosi K, Jacyna J, Dabrowska M, Potas J, Jan Markuszewski M Pharmaceutics. 2020; 12(5).

PMID: 32429349 PMC: 7284795. DOI: 10.3390/pharmaceutics12050455.

the Material Properties of Chitosan-Halloysite Hydrogel Composites.

Luo Y, Mills D Gels. 2019; 5(3).

PMID: 31416252 PMC: 6787627. DOI: 10.3390/gels5030040.

Adsorption of aquaculture pollutants using a sustainable biopolymer.

Zadinelo I, Dos Santos L, Cagol L, de Muniz G, de Souza Neves Ellendersen L, Alves H Environ Sci Pollut Res Int. 2017; 25(5):4361-4370.

PMID: 29181757 DOI: 10.1007/s11356-017-0794-4.

Development and Evaluation of pH-Dependent Micro Beads for Colon Targeting.

Khan M, Sridhar B, Srinatha A Indian J Pharm Sci. 2010; 72(1):18-23.

PMID: 20582185 PMC: 2883222. DOI: 10.4103/0250-474X.62230.

References

Thanoo B, Sunny M, Jayakrishnan A . Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J Pharm Pharmacol. 1992; 44(4):283-6. DOI: 10.1111/j.2042-7158.1992.tb03607.x. View

Pile J, Malone J, Eitzen E, Friedlander A . Anthrax as a potential biological warfare agent. Arch Intern Med. 1998; 158(5):429-34. DOI: 10.1001/archinte.158.5.429. View

Knutson D, Greenberg G, Cronau H . Management of Crohn's disease--a practical approach. Am Fam Physician. 2003; 68(4):707-14. View

Dhawan S, Singla A . Nifedipine loaded chitosan microspheres prepared by emulsification phase-separation. Biotech Histochem. 2004; 78(5):243-54. View

Peppas N . Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985; 60(4):110-1. View

Korsmeyer R, Gurny R, Doelker E, Buri P, Peppas N . Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci. 1983; 72(10):1189-91. DOI: 10.1002/jps.2600721021. View

Binkley C, Cinti S, Simeone D, Colletti L . Bacillus anthracis as an agent of bioterrorism: a review emphasizing surgical treatment. Ann Surg. 2002; 236(1):9-16. PMC: 1422543. DOI: 10.1097/00000658-200207000-00004. View

Higuchi T . MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. J Pharm Sci. 1963; 52:1145-9. DOI: 10.1002/jps.2600521210. View

Durkut S, Elcin Y, Elcin A . Biodegradation of chitosan-tripolyphosphate beads: in vitro and in vivo studies. Artif Cells Blood Substit Immobil Biotechnol. 2006; 34(2):263-76. DOI: 10.1080/10731190600581866. View

10.

Hejazi R, Amiji M . Chitosan-based gastrointestinal delivery systems. J Control Release. 2003; 89(2):151-65. DOI: 10.1016/s0168-3659(03)00126-3. View

11.

Ko J, Park H, Hwang S, Park J, Lee J . Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm. 2002; 249(1-2):165-74. DOI: 10.1016/s0378-5173(02)00487-8. View

12.

Blondeau J . Current issues in the management of urinary tract infections: extended-release ciprofloxacin as a novel treatment option. Drugs. 2004; 64(6):611-28. DOI: 10.2165/00003495-200464060-00004. View

13.

Gibaldi M, Feldman S . Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms. J Pharm Sci. 1967; 56(10):1238-42. DOI: 10.1002/jps.2600561005. View

14.

Shu X, Zhu K . Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure. Int J Pharm. 2002; 233(1-2):217-25. DOI: 10.1016/s0378-5173(01)00943-7. View

15.

Wagner J . Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules. J Pharm Sci. 1969; 58(10):1253-7. DOI: 10.1002/jps.2600581021. View

16.

Reza M, Quadir M, Haider S . Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery. J Pharm Pharm Sci. 2003; 6(2):282-91. View

17.

Bodmeier R, Paeratakul O . Spherical agglomerates of water-insoluble drugs. J Pharm Sci. 1989; 78(11):964-7. DOI: 10.1002/jps.2600781117. View

18.

Orienti I, Aiedeh K, Gianasi E, Bertasi V, Zecchi V . Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics. J Microencapsul. 1996; 13(4):463-72. DOI: 10.3109/02652049609026031. View