Lipid Metabolism in Trypanosoma Brucei

Overview

Journal Mol Biochem Parasitol

Specialties Biochemistry
Molecular Biology
Parasitology

Date 2010 Apr 13

PMID 20382188

Citations 57

Authors

Terry K Smith

Peter Butikofer

Affiliations

Soon will be listed here.

Abstract

Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites.

Citing Articles

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