Amyloid in Endomyocardial Biopsies

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2010 Apr 9

PMID 20376481

Citations 17

Authors

Barbara Kieninger

Magdalena Eriksson

Reinhard Kandolf

Philipp A Schnabel

Stefan Schonland

Arnt V Kristen

Ute Hegenbart

Peter Lohse

Christoph Rocken

Affiliations

Soon will be listed here.

Abstract

The prognosis of cardiac amyloidosis depends on the nature and origin of the amyloid protein deposited. However, little is known about the prevalence and origin of amyloid in heart muscle biopsies. We therefore examined retrospectively the distribution and origin of amyloid in a consecutive series of endomyocardial biopsies. Endomyocardial biopsies with verified presence of amyloid from 101 patients were included. Amyloid was classified immunohistochemically in each of them. Our collective comprised 63 men and 38 women, with a mean age of 66 years (range 37-85 years). Cardiac amyloidosis was the most common of the AL (54 patients) or ATTR type (42 patients). In five individuals, amyloid remained unclassified. AL amyloidosis was subdivided into ALlambda (45 patients) and ALkappa amyloid (nine patients). AA amyloid was not found in any individual. The amount of amyloid was higher in AL than in ATTR amyloidosis. Genomic DNA was extracted and examined by DNA sequencing in 19 patients with ATTR amyloidosis. Five (26%) individuals carried TTR mutations (p.Val20Ile, p.Val30Met (twice), p.Asp39Val and p.Glu54Asp) and were classified as suffering from hereditary ATTR amyloidosis. Amyloid in endomyocardial biopsies is most commonly of immunoglobulin light chain origin, followed by non-hereditary and hereditary-type ATTR amyloid.

Citing Articles

Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy.

Aurich M, Bucur J, Vey J, Greiner S, Aus dem Siepen F, Hegenbart U Open Heart. 2023; 10(2).

PMID: 37463823 PMC: 10357742. DOI: 10.1136/openhrt-2023-002310.

Tip of the iceberg: a tertiary care centre retrospective study of left ventricular hypertrophy aetiologies.

Beneyto M, Cariou E, Brunel J, Scripcariu A, Delasnerie H, Brun S Open Heart. 2021; 8(1).

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Mass spectrometry-based absolute quantification of amyloid proteins in pathology tissue specimens: Merits and limitations.

Ogawa M, Shintani-Domoto Y, Nagashima Y, Ode K, Sato A, Shimizu Y PLoS One. 2020; 15(7):e0235143.

PMID: 32609750 PMC: 7329117. DOI: 10.1371/journal.pone.0235143.

Cardiac amyloidosis: The great masquerader.

Rind J, Chalfoun N, McNamara R Glob Cardiol Sci Pract. 2018; 2018(2):18.

PMID: 30083548 PMC: 6062763. DOI: 10.21542/gcsp.2018.18.

Restrictive Cardiomyopathies: The Importance of Noninvasive Cardiac Imaging Modalities in Diagnosis and Treatment-A Systematic Review.

Rammos A, Meladinis V, Vovas G, Patsouras D Radiol Res Pract. 2017; 2017:2874902.

PMID: 29270320 PMC: 5705874. DOI: 10.1155/2017/2874902.

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