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Oridamycins A and B, Anti-Saprolegnia Parasitica Indolosesquiterpenes Isolated from Streptomyces Sp. KS84

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Journal J Nat Prod
Date 2010 Apr 8
PMID 20369841
Citations 18
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Abstract

Oridamycins A (1) and B (2) were isolated from the fermentation broth of Streptomyces sp. strain KS84 as selective anti-Saprolegnia parasitica antibiotics. Their structures were elucidated as pentacyclic indolosesquiterpenes by the combination of NMR and spectroscopic analyses. The absolute configuration of 1 was determined by ROESY analyses after the advanced Mosher analysis. Compound 1 exhibited anti-S. parasitica activity with an MIC value of 3.0 microg/mL, but was much less active against the phytopathogenic fungus Phoma sp. and the yeast Saccharomyces cerevisiae.

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