Development of a Vaccine to Prevent Japanese Encephalitis: a Brief Review

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2010 Apr 3

PMID 20360904

Citations 4

Authors

Viroj Wiwanitkit

Affiliations

Soon will be listed here.

Abstract

Japanese encephalitis (ICD 10: A83.0) is an important specific viral encephalitis caused by the Japanese encephalitis virus, a virus of the Flavivirus group. Millions of people, especially those in endemic areas of developing countries in Asia, are at high risk from this infection. Therefore proper management to deal with this virus is essential. There is no specific treatment for Japanese encephalitis virus. Supportive and symptomatic treatments are usually used, which emphasize the importance of prevention in this specific neurological disorder. Vector control or vaccination can be used to prevent the disease. Because the existing Japanese encephalitis vaccine poses some undesirable problems, a new vaccine is needed. The process of developing a new vaccine is briefly discussed.

Citing Articles

Development and validation of an assay for detection of Japanese encephalitis virus specific antibody responses.

Pushpakumara P, Jeewandara C, Gomes L, Perera Y, Wijewickrama A, Malavige G PLoS One. 2020; 15(10):e0238609.

PMID: 33112881 PMC: 7592747. DOI: 10.1371/journal.pone.0238609.

Computer-Assisted and Data Driven Approaches for Surveillance, Drug Discovery, and Vaccine Design for the Zika Virus.

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Prevalence of Neutralizing Antibodies to Japanese Encephalitis Virus among High-Risk Age Groups in South Korea, 2010.

Lee E, Cha G, Ju Y, Han M, Lee W, Jeong Y PLoS One. 2016; 11(1):e0147841.

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Heterogeneous nuclear ribonucleoprotein A2 participates in the replication of Japanese encephalitis virus through an interaction with viral proteins and RNA.

Katoh H, Mori Y, Kambara H, Abe T, Fukuhara T, Morita E J Virol. 2011; 85(21):10976-88.

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